Recent advances in bone tissue engineering scaffolds.
TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
Citations
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Selective laser sintering of β-TCP/nano-58S composite scaffolds with improved mechanical properties
TL;DR: In this article, nano-sized 58S bioactive glass (nano-58S) as the dispersed phase was added to β-tricalcium phosphate (β-TCP) to reinforce the mechanical properties.
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Fabrication of trabecular-like beta-tricalcium phosphate biomimetic scaffolds for bone tissue engineering
TL;DR: In this paper, a biomimetic porous β-tricalcium phosphate (β-TCP) scaffolds with trabecular-like morphology were obtained based on three dimension (3D) Voronoi tessellation method and generated design.
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Antheraea pernyi silk fibroin for targeted gene delivery of VEGF165-Ang-1 with PEI.
TL;DR: This study provides a novel method for decreasing the cytotoxicity of PEI gene delivery vectors and increasing transfection efficiency of angiogenesis-related genes.
Journal ArticleDOI
Inversely 3D-Printed β-TCP Scaffolds for Bone Replacement
Michael Seidenstuecker,Svenja Lange,Svenja Lange,Steffen Esslinger,Sergio H. Latorre,Rumen Krastev,Rainer Gadow,Hermann O. Mayr,Anke Bernstein +8 more
TL;DR: The experiments on which this work is based have shown that the fused deposition modeling process with subsequent slip casting and sintering is well suited for the production of scaffolds for bone replacement.
Book ChapterDOI
Commercial Products for Osteochondral Tissue Repair and Regeneration
TL;DR: The good manufacturing practices, regulatory medical conditions and challenges on clinical translations that should be fulfilled regarding the safety and efficacy of the new commercialized products are discussed.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.