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Open AccessJournal ArticleDOI

Recent advances in bone tissue engineering scaffolds.

Susmita Bose, +2 more
- 01 Oct 2012 - 
- Vol. 30, Iss: 10, pp 546-554
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TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.
About
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.

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Citations
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Fabrication, characterisation and in vitro biological activities of a sulfuretin-supplemented nanofibrous composite scaffold for tissue engineering

TL;DR: Sulfuretin is suggested to be an effective supplemental bioactive agent for enhancing bone tissue growth on fibrous composite scaffolds through electrospinning/plasma-treatment/coating.
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Hydroxyapatite Synthesis from Fish Bones: Atlantic Salmon (Salmon Salar)

TL;DR: In this paper, a hydroxyapatite synthesis from fish bones is presented. But the authors focus on the Atlantic Salmon (Salmon Salar) and do not consider the other species of fishes.
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Investigation on dimensional accuracy, compressive strength and measured porosity of additively manufactured calcium sulphate porous bone scaffolds

TL;DR: Additive manufacturing (AM) assisted by modern design tools has shown a great potential for fabricating synthetic bone scaffolds as mentioned in this paper, which offers better control over structural features of por...
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In vivo evaluation of a novel nanocomposite porous 3D scaffold in a rabbit model: histological analysis

TL;DR: Trials in animal models proved that the innovative porous 3D scaffolds implant of CaCO3 aragonite nanocomposite derived from cockle shell has the capability of enduring load-bearing conditions for long-term use devoid of breaking or generating stress that affects the host bone.
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Physico-chemical and in vitro cellular properties of different calcium phosphate-bioactive glass composite chitosan-collagen (CaP@ChiCol) for bone scaffolds.

TL;DR: In the present study, scaffolds for bone tissue engineering applications were made by immersing the inorganic phases of three different calcium phosphate (CaPs) mixing bioactive glass with polycaprolactone as a binder in an organic phase of chitosan/collagen (ChiCol) matrix, showing promise for bone regeneration.
References
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Journal ArticleDOI

Porosity of 3D biomaterial scaffolds and osteogenesis.

TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic

TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article

Bioceramics : from concept to clinic

TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering

TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
Journal ArticleDOI

The Extracellular Matrix: Not Just Pretty Fibrils

TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.
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