Recent advances in bone tissue engineering scaffolds.
TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
Citations
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Osteogenic lineage restriction by osteoprogenitors cultured on nanometric grooved surfaces: the role of focal adhesion maturation.
John W. Cassidy,J.N. Roberts,Carol-Anne Smith,Mary Robertson,Kate White,Manus J.P. Biggs,Richard O.C. Oreffo,Matthew J. Dalby +7 more
TL;DR: In this article, the FDA-approved plastic polycaprolactone was embossed with nanometric grooves and the response of primary and immortalized osteoprogenitor cells observed.
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Engineering Photocrosslinkable Bicomponent Hydrogel Constructs for Creating 3D Vascularized Bone.
Mehdi Kazemzadeh-Narbat,Mehdi Kazemzadeh-Narbat,Jeroen Rouwkema,Jeroen Rouwkema,Jeroen Rouwkema,Nasim Annabi,Hao Cheng,Hao Cheng,Masoumeh Ghaderi,Masoumeh Ghaderi,Byung-Hyun Cha,Byung-Hyun Cha,Mansi Aparnathi,Mansi Aparnathi,Akbar Khalilpour,Akbar Khalilpour,Batzaya Byambaa,Batzaya Byambaa,Esmaiel Jabbari,Ali Tamayol,Ali Tamayol,Ali Tamayol,Ali Khademhosseini +22 more
TL;DR: It is shown that the simultaneous presence of both osteogenic and angiogenic niches in one construct results in formation of mineralized regions surrounded by organized vasculature.
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Bone Regeneration Using Gene-Activated Matrices
Sheetal R. D’Mello,Keerthi Atluri,Sean M. Geary,Liu Hong,Satheesh Elangovan,Aliasger K. Salem +5 more
TL;DR: Tissue engineering strategies to regenerate bone with specific focus on non-viral gene delivery systems are discussed, including gene-activated matrices, which can be achieved in a way that stimulates osteogenesis and bone repair within osseous defects.
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Starch-Hydroxyapatite Composite Bone Scaffold Fabrication Utilizing a Slurry Extrusion-Based Solid Freeform Fabricator.
TL;DR: Overall, the utilization of starch as a natural binder system in SFF scaffolds was found to improve both green strength and in vitro biocompatibility.
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Toward mimicking the bone structure: design of novel hierarchical scaffolds with a tailored radial porosity gradient.
Andrea Di Luca,Alessia Longoni,Giuseppe Criscenti,Giuseppe Criscenti,Carlos Mota,Clemens van Blitterswijk,Clemens van Blitterswijk,Lorenzo Moroni,Lorenzo Moroni +8 more
TL;DR: A new scaffold design with a built-in gradient in porosity, which approximate the radial bone structure is presented, and osteogenic differentiation was influenced by pore size and location in scaffolds displaying a radial porosity gradient.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.