Recent advances in bone tissue engineering scaffolds.
TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
Citations
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Degradation and Characterisation of Electrospun Polycaprolactone (PCL) and Poly(lactic-co-glycolic acid) (PLGA) Scaffolds for Vascular Tissue Engineering.
Morteza Bazgir,Wei Zhang,Ximu Zhang,Jacobo Elies,Morvarid Saeinasab,Phil Coates,Mansour Youseffi,Farshid Sefat +7 more
TL;DR: In this paper, the structural properties of poly(lactic-co-glycolic acid) (PLGA)- and polycaprolactone (PCL)-based nanofibrous scaffolds were evaluated.
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A novel 3D indirect co-culture system based on a collagen hydrogel scaffold for enhancing the osteogenesis of stem cells
Hyerim Kim,Shi Huan Han,Yun Min Kook,Kyung Mee Lee,Yuan Zhe Jin,Won Gun Koh,Jae Hyup Lee,Kangwon Lee +7 more
TL;DR: The system developed in this study provides a novel in vitro tissue model for bone regeneration without exogenous factors, and it has the potential to be used to study the paracrine effect in various co-culture systems in the near future.
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Biomacromolecule based nanoscaffolds for cell therapy
Samira Jafari,Elham Ahmadian,Elham Ahmadian,Javad Khalili Fard,Javad Khalili Fard,Ahmad Yari Khosroushahi +5 more
TL;DR: This study reviewed comprehensively ideal nanoscaffold properties and their preparation methods based on several attractive biomacromoelecules such as silk, collagen, hyaluronic acid, chitosan, alginate, fibrin in the view of their advantages/disadvantages of using them in the cell therapy/tissue engineering.
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Porous and biodegradable polycaprolactone-borophosphosilicate hybrid scaffolds for osteoblast infiltration and stem cell differentiation.
TL;DR: Scaffolds containing 2-mol% boron had an optimum effect on lineage expressions for alkaline phosphatase (ALP), osteopontin (OPN) and osteocalcin (OCN), suggesting that PCL/BPSG hybrid scaffolds with optimum-level bor on enhance bone formation.
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A comparative study of monoaxial and coaxial PCL/gelatin/Poloxamer 188 scaffolds for bone tissue engineering
TL;DR: Novel PCL/P-188(Shell) coaxial scaffold had superior stability, average weight loss, no swelling behavior, controlled release of Beta-lactoglobulin and vitamin K2, enhanced Saos-2 cell viability and ALP activity and could be a good candidate as a bone tissue scaffold.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.