Recent advances in bone tissue engineering scaffolds.
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TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
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Indirect selective laser sintering-printed microporous biphasic calcium phosphate scaffold promotes endogenous bone regeneration via activation of ERK1/2 signaling.
Hao Zeng,Janak L. Pathak,Yusheng Shi,Jiabing Ran,Liang Liang,Qi Yan,Tao Wu,Qihang Fan,Mengxun Li,Yi Bai +9 more
TL;DR: An indirect selective laser sintering (SLS) printing strategy to fabricate 3D microporous BCP scaffolds maintains the physicochemical properties of BCP and possess the capacity to recruit host precursor cells to the defect site and promote the endogenous bone regeneration possibly via activation of ERK1/2 signaling.
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Osteogenic performance of donor-matched human adipose and bone marrow mesenchymal cells under dynamic culture.
TL;DR: Scaffolds seeded with BMCs in dynamic stirring culture conditions exhibit the greatest osteogenic proliferation and function in vitro, proving that marrow-derived MC have superior bone-forming potential as compared with adipose-derived cells.
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Enhanced in vitro osteoblast differentiation on TiO2 scaffold coated with alginate hydrogel containing simvastatin.
Helen Pullisaar,Hanna Tiainen,Maria A. Landin,Ståle Petter Lyngstadaas,Håvard J. Haugen,Janne E. Reseland,Esben Østrup +6 more
TL;DR: Results indicate that simVastatin-coated TiO2 scaffolds can support a sustained release of simvastatin and induce osteoblast differentiation, and may represent a new strategy for bone regeneration in defects where immediate load is wanted or unavailable.
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Functionalized d-form self-assembling peptide hydrogels for bone regeneration.
Bin He,Yunsheng Ou,Ao Zhou,Shuo Chen,Weikang Zhao,Jinqiu Zhao,Hong Li,Yong Zhu,Zenghui Zhao,Dianming Jiang +9 more
TL;DR: It is demonstrated that RGD-modified d-form peptide scaffolds are able to enhance extensive bone regeneration and fill the femoral condyle defect of Sprague Dawley rat model.
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The Role of In Vitro Immune Response Assessment for Biomaterials
TL;DR: With recent studies suggesting poor correlation between current in vitro and in vivo testing of biomaterials, in vitro immune response assays may be more relevant and enhance ability in predicting acceptance prior to in vivo application.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.