Recent advances in bone tissue engineering scaffolds.
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TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
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Niobium pentoxide and hydroxyapatite particle loaded electrospun polycaprolactone/gelatin membranes for bone tissue engineering
Natália H. Marins,Bryan E.J. Lee,Ricardo Marques e Silva,Arjun Raghavan,Neftalí L. V. Carreño,Kathryn Grandfield +5 more
TL;DR: Electrospun membranes containing HA and Nb2O5 particles have potential to promote cell adhesion and proliferation while exhibiting bioactive properties and PGHANb membranes are promising candidates for bone tissue engineering applications.
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Synergistic combination of bioactive glasses and polymers for enhanced bone tissue regeneration
Saeid Kargozar,Masoud Mozafari,Robert G. Hill,Peiman Brouki Milan,Mohammad Taghi Joghataei,Sepideh Hamzehlou,Francesco Baino +6 more
TL;DR: The combination of micro- or nano-sized BG inclusions with different synthetic and natural polymers is proposed as an effective approach to produce composite scaffolds which can be used in a variety of dental and orthopaedic applications.
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Mechano-Biological Computer Model of Scaffold-Supported Bone Regeneration: Effect of Bone Graft and Scaffold Structure on Large Bone Defect Tissue Patterning.
TL;DR: Graft osteoconductive properties and scaffold-surface guided extracellular matrix deposition are found to be essential features driving bone defect filling in a 3D-printed honeycomb titanium structure, paving the way for the design of more effective 3D scaffold structures and their pre-clinical optimization, prior to their application in scaffolds-based bone defect regeneration.
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Poly(trimethylene carbonate) and nano-hydroxyapatite porous scaffolds manufactured by stereolithography
Olivier Guillaume,Mike A. Geven,Dirk W. Grijpma,Tingting Tang,Ling Qin,Yuxiao Lai,Huipin Yuan,R.G. Richards,David Eglin +8 more
TL;DR: In this paper, a poly(trimethylene carbonate) (PTMC) and nano-hydroxyapatite (HA) resins were used for photo-crosslink-based SLA fabrication of 3D porous structures.
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Production of new 3D scaffolds for bone tissue regeneration by rapid prototyping
R. Fradique,Tiago Ruivo Correia,Sónia P. Miguel,K. D. de Sá,Daniela Sofia Rodrigues Figueira,António G. Mendonça,Ilídio J. Correia +6 more
TL;DR: The results showed that 60/40 of TCP and alginate formulation was able to match the compression and present a similar Young modulus to that of trabecular bone while presenting an adequate biocompatibility.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.