Recent advances in bone tissue engineering scaffolds.
TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
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Development of electrospun poly (vinyl alcohol)‐based bionanocomposite scaffolds for bone tissue engineering
Mohammad Saied Enayati,Mohammad Saied Enayati,Tayebeh Behzad,Paweł Sajkiewicz,Mohammad Rafienia,Rouhollah Bagheri,Laleh Ghasemi-Mobarakeh,Dorota Kołbuk,Zari Pahlevanneshan,Shahin Bonakdar +9 more
TL;DR: The obtained results confirm that the 3-componemnt fibrous scaffold of PVA/nHAp/CNF has promising potential in hard TE.
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Fabrication of a chitosan/bioglass three-dimensional porous scaffold for bone tissue engineering applications.
TL;DR: In vitro cell assay results demonstrated that the CS/BG 3D porous scaffold had good biocompatibility, which facilitates the spreading and proliferation of human bone marrow stromal cells (hBMSCs) and is thus a suitable material for bone tissue engineering.
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Undifferentiated human adipose‐derived stromal/stem cells loaded onto wet‐spun starch–polycaprolactone scaffolds enhance bone regeneration: Nude mice calvarial defect in vivo study
Pedro P. Carvalho,Pedro P. Carvalho,Isabel B. Leonor,Brenda J. Smith,Isabel R. Dias,Isabel R. Dias,Rui L. Reis,Jeffrey M. Gimble,Manuela E. Gomes +8 more
TL;DR: Nondifferentiated human ASCs enhance ossification of nonhealing nude mice calvarial defects, and wet-spun SPCL confirmed its suitability for bone tissue engineering.
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Injectable chitosan/gelatin/bioactive glass nanocomposite hydrogels for potential bone regeneration: In vitro and in vivo analyses.
Cheisy D.F. Moreira,Sandhra M. Carvalho,Rodrigo M. Florentino,Andressa França,Bárbara Silva Okano,Cleuza Maria de Faria Rezende,Herman S. Mansur,Marivalda M. Pereira +7 more
TL;DR: The data suggest that the developed injectable composite hydrogels possess properties which make them suitable candidates for use as temporary injectable matrices for bone regeneration, and could be candidates for a safe in situ gel-forming system.
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A Simple Approach for an Eggshell-Based 3D-Printed Osteoinductive Multiphasic Calcium Phosphate Scaffold
Prabhash Dadhich,Bodhisatwa Das,Pallabi Pal,Pavan Kumar Srivas,Joy Dutta,Sabyasachi Ray,Santanu Dhara +6 more
TL;DR: The eggshell-derived multiphasic calcium phosphate scaffold displayed improvement in the mechanical properties with higher porosity and osteoinductivity compared to the chemically derived apatite and unveiled a new paradigm for utilization of biological wastes in bone-graft application.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.