Recent advances in bone tissue engineering scaffolds.
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TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
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Mechanical properties and biocompatibility of porous titanium scaffolds for bone tissue engineering.
Yunhui Chen,Jessica E. Frith,Ali Dehghan-Manshadi,Hooyar Attar,Damon Kent,Nicolas Soro,Michael Bermingham,Matthew S. Dargusch +7 more
TL;DR: It is concluded that samples with 30% porosity exhibit the best biocompatibility and suggest that porous titanium scaffolds generated using this manufacturing route have excellent potential for hard tissue engineering applications.
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In vitro Models of Bone Remodelling and Associated Disorders
Robert Owen,Gwendolen C. Reilly +1 more
TL;DR: The need for the use of cells capable of endogenously producing the required cytokines, application of mechanical stimulation, and the presence of appropriate hormones in order to produce a robust model of bone remodelling is detailed.
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Stem cell-based bone and dental regeneration: a view of microenvironmental modulation
TL;DR: Current knowledge regarding the tactics of MSC-based bone and dental regeneration and the decisive role of the microenvironment are summarized, emphasizing the therapeutic potential of microenvironment-targeting strategies in bone and dentist regenerative medicine.
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Cell-laden 3D bioprinting hydrogel matrix depending on different compositions for soft tissue engineering: Characterization and evaluation.
TL;DR: Alginate-based bioinks prepared with High and Low Alg at a 2:1 ratio exhibited better cell growth compared with those of other compositions, which allowed for the construction of 3D scaffolds with good processability and shapes.
Journal Article
Porous metal for orthopedics implants.
TL;DR: An overview about biomaterials properties of the contemporary class of highly porous metals and about the clinical use in orthopaedic surgery is given.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.