Recent advances in bone tissue engineering scaffolds.
TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
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3D printing of Cu-doped bioactive glass composite scaffolds promotes bone regeneration through activating the HIF-1α and TNF-α pathway of hUVECs.
Qiyuan Dai,Qingtao Li,Huichang Gao,Longtao Yao,Zefeng Lin,Dingguo Li,Shuangli Zhu,Cong Liu,Zhen Yang,Gang Wang,Dafu Chen,Xiaofeng Chen,Xiaodong Cao +12 more
TL;DR: In this article, a 3D-printed gelatin/silk fibroin/copper-doped bioactive glass (Gel/SF/Cu-BG) scaffold for rat bone defects was constructed and the mechanism of the profound angiogenesis effect regulated by copper was explored in vivo.
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Effect of Electron Beam Sterilization on Three-Dimensional-Printed Polycaprolactone/Beta-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering.
TL;DR: It is proven in this article that E-beam irradiation is relevant for sterilization of 3D-printed PCL/β-TCP scaffolds for bone tissue engineering applications.
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Calcium Silicate Improved Bioactivity and Mechanical Properties of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Scaffolds.
Cijun Shuai,Wang Guo,Chengde Gao,Youwen Yang,Yong Xu,Long Liu,Tian Qin,Hang Sun,Sheng Yang,Pei Feng,Ping Wu +10 more
TL;DR: Results suggest that the PHBV/CS composite scaffolds have the potential in serving as a substitute in bone tissue engineering.
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Three-dimensional CaP/gelatin lattice scaffolds with integrated osteoinductive surface topographies for bone tissue engineering
TL;DR: Both in vitro and in vivo studies show that micropatterned composite scaffolds with surfaces comprising 40 μm pits and 50 μm grooves were optimal for improved osteogenesis and demonstrated the potential of a novel fabrication process for producing cell-instructive scaffold with designed surface topographies to induce specific tissue regeneration.
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Metal-organic framework-based nanomaterials for bone tissue engineering and wound healing
Mahsa Asadniaye Fardjahromi,Hojjatollah Nazari,Seyed Mohsen Ahmadi Tafti,Amir Razmjou,Subhabrata Mukhopadhyay,Majid Ebrahimi Warkiani +5 more
TL;DR: In this paper , a review of recent applications of nano-MOFs for bone and wound healing is comprehensively discussed, and challenges, clinical barriers, and considerations for implementing these nanomaterials in different scaffolds, tissue-like structures, implants, fillers, and dressers in the orthopedic and wound clinics are comprised.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.