Recent advances in bone tissue engineering scaffolds.
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TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
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Engineering bone-implant integration with photofunctionalized titanium microfibers.
TL;DR: It is hypothesized that photofunctionalized titanium microfibers are capable of promoting bone ingrowth into the microfiber scaffold to improve bone-implant integration in bone defects and may provide a novel and effective strategy to regenerate and integrate bone in a wider range of applications.
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Enhancement of stem cell differentiation to osteogenic lineage on hydroxyapatite-coated hybrid PLGA/gelatin nanofiber scaffolds.
TL;DR: HA-PLGA/gelatin electrospun scaffolds were demonstrated to have significant potential for bone tissue engineering applications and it was shown that nanofibrous structure enhanced osteogenic differentiation of adipose-tissue derived stem cells.
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Oxygen Tension-Controlled Matrices with Osteogenic and Vasculogenic Cells for Vascularized Bone Regeneration In Vivo.
TL;DR: In this article, a two-pronged approach for vascularized bone regeneration in vivo was introduced and evaluated for critical-sized/segmental bone defect repair in orthopedic surgery.
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The impact of Zn-doped synthetic polymer materials on bone regeneration: a systematic review.
TL;DR: A systematic review of the application and effectiveness of Zn2+ in synthetic polymers for bone regeneration, whether used alone or in combination with other biomaterials was performed according to the PRISMA guidelines.
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Synthesis and in vivo evaluation of a scaffold containing wollastonite/β-TCP for bone repair in a rabbit tibial defect model
Willams Teles Barbosa,Katilayne Vieira de Almeida,Gabriel Goetten de Lima,Gabriel Goetten de Lima,Miguel A. Rodríguez,Marcos V Lia Fook,Raúl García-Carrodeguas,Valdemiro Amaro da Silva Junior,Francisco Alipio de Sousa Segundo,Marcelo Jorge Cavalcanti de Sá,Marcelo Jorge Cavalcanti de Sá +10 more
TL;DR: The studied calcium silicate implant provided biocompatibility and promoted bone formation, stimulating the process of bone repair in rabbits, features observed by gradual radiopacity shown in the radiographic evaluations.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.