Recent advances in bone tissue engineering scaffolds.
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TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
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Three-Dimensional Printing of Hollow-Struts-Packed Bioceramic Scaffolds for Bone Regeneration
Yongxiang Luo,Yongxiang Luo,Dong Zhai,Zhiguang Huan,Haibo Zhu,Lunguo Xia,Jiang Chang,Chengtie Wu +7 more
TL;DR: A useful and facile method for preparing hollow-struts-packed (HSP) bioceramic scaffolds with designed macropores and multioriented hollow channels via a modified coaxial 3D printing strategy is presented, indicating a universal application for tissue engineering, mechanical engineering, catalysis, and environmental materials.
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A Magnesium-Enriched 3D Culture System that Mimics the Bone Development Microenvironment for Vascularized Bone Regeneration.
Sihan Lin,Guangzheng Yang,Fei Jiang,Mingliang Zhou,Shi Yin,Yanmei Tang,Tingting Tang,Zhiyuan Zhang,Wenjie Zhang,Xinquan Jiang +9 more
TL;DR: A series of experiments show that the Mg‐enriched microenvironment not only stimulates the osteogenic differentiation of stem cells but also promotes neovascularization, suggesting that biomaterials mimicking the developmental microenvironment might be promising tools to enhance tissue regeneration.
Journal ArticleDOI
A pH-Triggered, Self-Assembled, and Bioprintable Hybrid Hydrogel Scaffold for Mesenchymal Stem Cell Based Bone Tissue Engineering.
Chen Zhao,Nader Taheri Qazvini,Monirosadat Sadati,Monirosadat Sadati,Zongyue Zeng,Shifeng Huang,Ana Losada de la Lastra,Linghuan Zhang,Yixiao Feng,Wei Liu,Bo Huang,Bo Huang,Bo Zhang,Zhengyu Dai,Yi Shen,Xi Wang,Wenping Luo,Bo Liu,Yan Lei,Zhenyu Ye,Ling Zhao,Daigui Cao,Lijuan Yang,Xian Chen,Aravind Athiviraham,Michael J. Lee,Jennifer Moriatis Wolf,Russell R. Reid,Matthew Tirrell,Matthew Tirrell,Wei Huang,Juan J. de Pablo,Juan J. de Pablo,Tong-Chuan He +33 more
TL;DR: The CMCh-ACP scaffold markedly enhances the efficiency and maturity of BMP9-induced bone formation in vivo, while suppressing bone resorption occurred in long-term ectopic osteogenesis, suggesting that the pH-responsive self-assembled CMch-ACP injectable and bioprintable hydrogel may be further exploited as a novel scaffold for osteoprogenitor-cell-based bone tissue regeneration.
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Evaluation of bone marrow stem cell response to PLA scaffolds manufactured by 3D printing and coated with polydopamine and type I collagen.
Bruna Nunes Teixeira,Paola Aprile,Roberta Helena Mendonça,Daniel J. Kelly,Rossana Mara da Silva Moreira Thiré +4 more
TL;DR: Results indicate that the osteoinductivity of 3D-printed PLA scaffolds can be enhanced by PDA and type I collagen coatings, which represents a promising strategy for bone tissue engineering.
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A review of bioceramic porous scaffolds for hard tissue applications: Effects of structural features
TL;DR: For in vitro and in vivo performances, pore size appeared more influential feature and co-existence of macropores and micropores led to better bone formation and scaffolds with porosities greater than 40% were more likely to substitute trabecular bones.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.