Recent advances in bone tissue engineering scaffolds.
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TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
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Basic Principles of Emulsion Templating and Its Use as an Emerging Manufacturing Method of Tissue Engineering Scaffolds.
TL;DR: This review focuses on the key points of how emulsion templated scaffolds can be fabricated for different TE applications and the applications of PolyHIPEs on soft and hard TE as well as in vitro models and drug delivery in the literature.
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The potential impact of bone tissue engineering in the clinic
TL;DR: Current regenerative medicine and restorative strategies that utilize tissue engineering approaches to address bone defects within a clinical setting are discussed and a probable workpath for translation from the laboratory to the clinic is suggested.
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Novel hydroxyethyl chitosan/cellulose scaffolds with bubble-like porous structure for bone tissue engineering.
TL;DR: The results from in vitro biocompatibility evaluated using SEM, live/dead cell viability and MTT assays demonstrated that the novel HECS/CEL scaffolds could well support the attachment, spreading and proliferation of osteoblastic MC3T3-E1 cells and showed good biOCompatibility.
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In vitro and in vivo studies of a gelatin/carboxymethyl chitosan/LAPONITE® composite scaffold for bone tissue engineering
TL;DR: In vivo cranial defect experiments revealed that the addition of Lap into the GC scaffold promoted bone regeneration, indicating that a composite scaffold with Lap incorporation is a promising material for bone tissue engineering.
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Dental Stem Cell-Derived Secretome/Conditioned Medium: The Future for Regenerative Therapeutic Applications.
Sara El Moshy,Israa Ahmed Radwan,Dina Rady,Marwa M.S. Abbass,Aiah A. El-Rashidy,Khadiga M. Sadek,Christof E. Dörfer,Karim M. Fawzy El-Sayed,Karim M. Fawzy El-Sayed +8 more
TL;DR: The analysis of these recent studies clearly indicate that dental MSCs' secretome/conditioned medium could be effective in treating neural injuries, for dental tissue regeneration, in repairing bone defects, and in managing cardiovascular diseases, diabetes mellitus, hepatic regeneration, and skin injuries, through regulating anti-inflammatory, antiapoptotic, angiogenic, osteogenic, and neurogenic mediators.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.