Recent advances in bone tissue engineering scaffolds.
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TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
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Journal ArticleDOI
Deciduous Dental Pulp Stem Cells for Maxillary Alveolar Reconstruction in Cleft Lip and Palate Patients
Daniela Yukie Sakai Tanikawa,Carla Cristina Gomes Pinheiro,Maria Cristina A. Almeida,Claudia Regina G. C. M. Oliveira,Renata de Almeida Coudry,Diógenes Laércio Rocha,Daniela Franco Bueno +6 more
TL;DR: Deciduous dental pulp stem cells associated with a hydroxyapatite-collagen sponge for closing alveolar defects during secondary dental eruption results in satisfactory bone healing with excellent feasibility and safety and adds significantly to the prospect of stem cell use in clinical settings.
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Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering
TL;DR: The results demonstrate that the borax cross-linked scaffold exhibits hydrogel behavior with appropriated mechanical properties for bone and cartilage tissue regeneration, without evident signs of cytotoxicity as it is evaluated in an in vitro system.
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Characterization and intracellular mechanism of electrospun poly (ε-caprolactone) (PCL) fibers incorporated with bone-dECM powder as a potential membrane for guided bone regeneration
Eunjeong Choi,Seungkuk Bae,Dongyun Kim,Gi Hoon Yang,KyoungHo Lee,Hi Jin You,Hyo Jin Kang,So-Jung Gwak,Sang-Hyun An,HoJun Jeon +9 more
TL;DR: The feasibility of the bdECM/PCL scaffold was demonstrated which can be used as a potential biomedical device for hard tissue regeneration and shows enhanced cell adhesion and proliferation.
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Manufacturing of graded titanium scaffolds using a novel space holder technique
Yunhui Chen,Damon Kent,Damon Kent,Michael Bermingham,Ali Dehghan-Manshadi,Gui Wang,Cuie Wen,Matthew S. Dargusch +7 more
TL;DR: This article shows that this powder metallurgy processing technique, employing the novel sugar pellets as space-holders, can generate porous titanium foams with well-controlled graded porosities and pore sizes, and has excellent potential for producing porous titanium structures for hard tissue engineering applications.
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Enhanced biocompatibility and osteogenic potential of mesoporous magnesium silicate/polycaprolactone/wheat protein composite scaffolds
TL;DR: Evaluation of the properties of fabricated scaffolds indicated that increasing the amount of WP improved the surface hydrophilicity and biodegradability of m_MS/PCL/WP composites, while reducing the mechanical strength.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.