Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine
TLDR
Individual HCC risk prediction is expected to overcome the challenge by enabling personalised chemoprevention, targeting high-risk patients for precision HCC prevention and substantially improving the dismal prognosis of HCC.About:
This article is published in Journal of Hepatology.The article was published on 2018-03-01 and is currently open access. It has received 457 citations till now. The article focuses on the topics: Precision medicine.read more
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2018 Korean Liver Cancer Association-National Cancer Center Korea practice guidelines for the management of hepatocellular carcinoma
Joong-Won Park,June Sung Lee,Kyung-Suk Suh,Jin Wook Chung,Jinsil Seong,Do Young Kim,Ji-Hoon Kim,Hyeong Jun Kim,Hwi Young Kim,Soo-Young Park,Joo Hyeon Shim,Jeong Hoon Lee,Young-Suk Lim,Ho Yeong Lim,Jeong Won Jang,Jae Young Jang,Dae Won Jeon,Yang Seok Ko,Kyung Sik Kim,Dong-Sik Kim,Seong Hoon Kim,Jong Man Kim,Yeong Cheol Yun,Dong Hwan Jeong,Jai Young Cho,Young Hwan Koh,Kyeong Min Kim,So Yeon Kim,Young Hwan Kim,In Joon Lee,Jeong Min Lee,Hyeon Cheol Lim,Sung Ki Cho,Ho Jong Cheon,Jun Il Choi,Chul Seung Kay,Mi Sook Kim,Tae Hyun Kim,Hee Chul Park,Sun Hyeon Bae,Sang Min Yoon,Won Sup Yoon,Won Il Jang +42 more
TL;DR: New recommendations that integrate the most up-to-date research findings and expert opinions are developed that will provide useful and constructive advice for the clinical management of patients with HCC.
Journal ArticleDOI
Hepatocellular carcinoma in the setting of alcohol-related liver disease.
TL;DR: Because of impaired surveillance and poor patient compliance, HCC is often detected late in patients with chronic liver disease of alcoholic aetiology, resulting in more advanced HCC that is less amenable to curative treatment.
Journal ArticleDOI
A Radiomics Nomogram for Preoperative Prediction of Microvascular Invasion in Hepatocellular Carcinoma.
Li Yang,Dongsheng Gu,Jingwei Wei,Chun Yang,Sheng-Xiang Rao,Wen-Tao Wang,Caizhong Chen,Ying Ding,Jie Tian,Mengsu Zeng +9 more
TL;DR: A radiomics nomogram incorporating clinicoradiological risk factors and radiomic features derived from HBP images achieved satisfactory preoperative prediction of the individualized risk of MVI in patients with HCC.
Journal ArticleDOI
HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response.
Nourdine Hamdane,Nourdine Hamdane,Frank Jühling,Frank Jühling,Emilie Crouchet,Emilie Crouchet,Houssein El Saghire,Houssein El Saghire,Christine Thumann,Christine Thumann,Marine A. Oudot,Marine A. Oudot,Simonetta Bandiera,Simonetta Bandiera,Antonio Saviano,Antonio Saviano,Clara Ponsolles,Clara Ponsolles,Armando Andres Roca Suarez,Armando Andres Roca Suarez,Shen Li,Naoto Fujiwara,Atsushi Ono,Atsushi Ono,Atsushi Ono,Irwin Davidson,Nabeel Bardeesy,Christian Schmidl,Christoph Bock,Christoph Bock,Christoph Bock,Catherine Schuster,Catherine Schuster,Joachim Lupberger,Joachim Lupberger,François Habersetzer,Michel Doffoel,Tullio Piardi,Daniele Sommacale,Michio Imamura,Takuro Uchida,Hideki Ohdan,Hiroshi Aikata,Kazuaki Chayama,Tujana Boldanova,Patrick Pessaux,Bryan C. Fuchs,Yujin Hoshida,Mirjam B. Zeisel,Mirjam B. Zeisel,Mirjam B. Zeisel,Francois H.T. Duong,Francois H.T. Duong,Francois H.T. Duong,Thomas Baumert +54 more
TL;DR: Integrative pathway analyses of liver tissues from patients and mice with humanized livers demonstrated that HCV-induced epigenetic alterations were associated with liver cancer risk, and these alterations might be targeted to prevent liver cancer in patients treated for HCV infection.
Journal ArticleDOI
Association Between Aspirin Use and Risk of Hepatocellular Carcinoma.
Tracey G. Simon,Yanan Ma,Yanan Ma,Jonas F. Ludvigsson,Jonas F. Ludvigsson,Jonas F. Ludvigsson,Dawn Q. Chong,Edward Giovannucci,Edward Giovannucci,Charles S. Fuchs,Jeffrey A. Meyerhardt,Kathleen E. Corey,Kathleen E. Corey,Raymond T. Chung,Xuehong Zhang,Andrew T. Chan +15 more
TL;DR: Regular, long-term aspirin use is associated with a dose-dependent reduction in HCC risk, which is apparent after 5 or more years of use, and similar associations were not found with nonaspirin NSAIDs.
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Santos,Maheswar Satpathy,Monika Sawhney,Mete Saylan,Peter Scarborough,Ben Schöttker,Jürgen C Schmidt,Ione Jayce Ceola Schneider,Austin E Schumacher,David C. Schwebel,James Scott,Sadaf G. Sepanlou,Edson Serván-Mori,Katya Anne Shackelford,Amira Shaheen,Saeid Shahraz,Marina Shakh-Nazarova,Siyi Shangguan,Jun She,Sara Sheikhbahaei,Donald S. Shepard,Kenji Shibuya,Yukito Shinohara,Kawkab Shishani,Ivy Shiue,Rupak Shivakoti,Mark G. Shrime,Inga Dora Sigfusdottir,Donald H. Silberberg,Andrea P. Silva,Edgar P. Simard,Shireen Sindi,Jasvinder A. Singh,Lavanya Singh,Edgar Sioson,Vegard Skirbekk,Karen Sliwa,Samuel So,Michael Soljak,Samir Soneji,Sergey Soshnikov,Luciano A. Sposato,Chandrashekhar T Sreeramareddy,Jeffrey D. Stanaway,Vasiliki Stathopoulou,Kyle Steenland,Claudia Stein,Caitlyn Steiner,Antony Stevens,Heidi Stöckl,Kurt Straif,Konstantinos Stroumpoulis,Lela Sturua,Bruno F. Sunguya,Soumya Swaminathan,Mamta Swaroop,Bryan L. Sykes,Karen M. Tabb,Ken Takahashi,Roberto Tchio Talongwa,Feng Tan,David Tanne,Marcel Tanner,Marcel Tanner,Mohammad Tavakkoli,Braden Te Ao,Carolina Maria Teixeira,Tara Templin,Eric Y. Tenkorang,Abdullah Sulieman Terkawi,Bernadette Thomas,Andrew L. Thorne-Lyman,Amanda G. Thrift,George D. Thurston,Taavi Tillmann,David L. Tirschwell,Imad M. Tleyjeh,Imad M. Tleyjeh,Marcello Tonelli,Fotis Topouzis,Jeffrey A. Towbin,Hideaki Toyoshima,Jefferson Traebert,Bach Xuan Tran,Thomas Truelsen,Ulises Trujillo,Matias Trillini,Zacharie Tsala Dimbuene,Miltiadis K. Tsilimbaris,E. Murat Tuzcu,Clotilde Ubeda,Uche S. Uchendu,Kingsley N. Ukwaja,Eduardo A. Undurraga,Andrew Vallely,Steven van de Vijver,Coen H. Van Gool,Yuri Y Varakin,Tommi Vasankari,Ana Maria Nogales Vasconcelos,Monica S. Vavilala,Narayanaswamy Venketasubramanian,Lakshmi Vijayakumar,Salvador Villalpando,Francesco Saverio Violante,Vasiliy Victorovich Vlassov,Gregory R. Wagner,Stephen G. Waller,JianLi Wang,Linhong Wang,Xiao Rong Wang,Yanping Wang,Tati S. Warouw,Scott Weichenthal,Elisabete Weiderpass,Robert G. Weintraub,Robert G. Weintraub,Wang Wenzhi,Andrea Werdecker,K. Ryan Wessells,Ronny Westerman,Harvey Whiteford,James D. Wilkinson,Thomas N. Williams,Solomon Meseret Woldeyohannes,Charles D.A. Wolfe,Timothy M. Wolock,Anthony D. Woolf,John Q. Wong,Jonathan L. Wright,Sarah Wulf,Brittany Wurtz,Gelin Xu,Yang Yang,Yuichiro Yano,Hiroshi Yatsuya,Paul S. F. Yip,Naohiro Yonemoto,Seok Jun Yoon,Mustafa Z. Younis,Chuanhua Yu,Kim Yun Jin,Maysaa El Sayed Zaki,Mohammed Fouad Zamakhshary,Hajo Zeeb,Yong Zhang,Yong Zhao,Yingfeng Zheng,Jun Zhu,Shankuan Zhu,David Zonies,Xiao Nong Zou,Joseph R. Zunt,Theo Vos,Alan D. Lopez,Alan D. Lopez,Christopher J L Murray,Gabriel Alcalá-Cerra,Howard Hu,Nadim E. Karam,Nsanzimana Sabin,A. M. Temesgen +731 more
TL;DR: In the Global Burden of Disease Study 2013 (GBD 2013) as discussed by the authors, the authors used the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data.
Journal ArticleDOI
Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology.
Bernard Levin,David A. Lieberman,Beth McFarland,Kimberly S. Andrews,Durado Brooks,John H. Bond,Chiranjeev Dash,Francis M. Giardiello,Seth N. Glick,David W. Johnson,C. Daniel Johnson,Theodore R. Levin,Perry J. Pickhardt,Douglas K. Rex,Robert A. Smith,Alan G. Thorson,Sidney J. Winawer +16 more
TL;DR: Clinicians should be prepared to offer patients a choice between a screening test that is effective at both early cancer detection and cancer prevention through the detection and removal of polyps and those that can detect cancer early and also can detect adenomatous polyps.
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Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level.
Chien-Jen Chen,Hwai I. Yang,Jun Su,C.-L. Jen,San Lin You,Sheng-Nan Lu,Guan-Tarn Huang,Uchenna H. Iloeje +7 more
TL;DR: Elevated serum HBV DNA level (> or =10,000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis.
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