Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
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TLDR
It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.About:
This article is published in Cell.The article was published on 2007-10-19 and is currently open access. It has received 2093 citations till now. The article focuses on the topics: Hematopoietic stem cell niche & Stromal cell.read more
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Generation of a Bone Organ by Human Adipose-Derived Stromal Cells Through Endochondral Ossification
Rik Osinga,Rik Osinga,Nunzia Di Maggio,Nunzia Di Maggio,Atanas Todorov,Atanas Todorov,Nima Allafi,Andrea Barbero,Andrea Barbero,Frédéric Laurent,Dirk J. Schaefer,Ivan Martin,Ivan Martin,Arnaud Scherberich,Arnaud Scherberich +14 more
TL;DR: Assessment of whether priming human ASC to a defined stage of chondrogenesis in vitro allows their autonomous ECO upon ectopic implantation concluded that human ASC can generate bone organs through ECO when suitably primed in vitro.
Journal ArticleDOI
In Vivo Labeling by CD73 Marks Multipotent Stromal Cells and Highlights Endothelial Heterogeneity in the Bone Marrow Niche
Martin Breitbach,Kenichi Kimura,Kenichi Kimura,Tiago C. Luis,Christopher J. Fuegemann,Petter S. Woll,Petter S. Woll,Michael Hesse,Raffaella Facchini,Sarah Rieck,Katarzyna Jobin,Julia Reinhardt,Osamu Ohneda,Daniela Wenzel,Caroline Geisen,Christian Kurts,Wolfgang Kastenmüller,Michael Hölzel,Sten Eirik W. Jacobsen,Bernd K. Fleischmann +19 more
TL;DR: The CD73-EGFP mouse is a powerful tool for studying MSCs and sinusoidal endothelium and reveals an endothelial subtype that also displays a mesenchymal signature, highlighting endothelial cell heterogeneity in the marrow.
Journal ArticleDOI
Genetic and epigenetic alterations of bone marrow stromal cells in myelodysplastic syndrome and acute myeloid leukemia patients.
Yonggoo Kim,Dong Wook Jekarl,Jiyeon Kim,Ahlm Kwon,Hayoung Choi,Seungok Lee,Yoo-Jin Kim,Hee-Je Kim,Yonghwan Kim,Il-Hoan Oh,Myungshin Kim +10 more
TL;DR: The characteristics of bone marrow stromal cells from patients of myelodysplastic syndrome and acute myeloid leukemia, and compared the results with control BMSCs derived from healthy donors, seem worthy of further evaluation of their association with ineffective hematopoiesis and leukemogenesis.
Journal ArticleDOI
Creation of new bone by the percutaneous injection of human bone marrow stromal cell and HA/TCP suspensions.
TL;DR: The data indicate that BMSCs and HA/TCP particles, when injected as a suspension, can assemble into mature bone organs, and that this bone has histologic and mechanical properties similar to bone formed in standard transplants delivered through a large incision.
Journal ArticleDOI
The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis
Jiang Wu,Weiwei Zhang,Qian Ran,Qian Ran,Yang Xiang,Yang Xiang,Jiang F. Zhong,Shengwen Calvin Li,Zhongjun Li +8 more
TL;DR: Current understanding about how BMSC differentiation affects hematopoiesis is summarized and its potential application in improving hematoietic recovery after bone marrow transplantation is summarized.
References
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Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Rafael A. Irizarry,Bridget G. Hobbs,Francois Collin,Yasmin Beazer-Barclay,Kristen J. Antonellis,Uwe Scherf,Terence P. Speed +6 more
TL;DR: There is no obvious downside to using RMA and attaching a standard error (SE) to this quantity using a linear model which removes probe-specific affinities, and the exploratory data analyses of the probe level data motivate a new summary measure that is a robust multi-array average (RMA) of background-adjusted, normalized, and log-transformed PM values.
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Mesenchymal stem cells
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Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
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Osteoblastic cells regulate the haematopoietic stem cell niche
Laura M. Calvi,Gregor B. Adams,Kathryn W. Weibrecht,Jonathan M. Weber,David P. Olson,M. C. Knight,Roderick P. Martin,Ernestina Schipani,P. Divieti,F. R. Bringhurst,Laurie A. Milner,Henry M. Kronenberg,David T. Scadden +12 more
TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
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SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
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Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more