Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
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TLDR
It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.About:
This article is published in Cell.The article was published on 2007-10-19 and is currently open access. It has received 2093 citations till now. The article focuses on the topics: Hematopoietic stem cell niche & Stromal cell.read more
Citations
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The aryl hydrocarbon receptor nuclear translocator is an essential regulator of murine hematopoietic stem cell viability
Bryan L. Krock,Tzipora S. Eisinger-Mathason,Dionysios N. Giannoukos,Dionysios N. Giannoukos,Jessica E.S. Shay,Mercy Gohil,David Lee,Michael S. Nakazawa,Julie Sesen,Nicolas Skuli,M. Celeste Simon,M. Celeste Simon +11 more
TL;DR: It is determined that ARNT is essential for adult and fetal HSC viability and homeostasis and conditional knockout of both HIF-1α and Hif-2α phenocopied key aspects of these HSC phenotypes, demonstrating that the impact of Arnt deletion is primarily HIF dependent.
Journal ArticleDOI
Skeletal Stem Cells for Bone Development and Repair: Diversity Matters.
TL;DR: Diverse groups of SSCs are likely to work in concert to achieve development and repair of the highly functional skeletal organ.
Journal ArticleDOI
Degenerative osteoarthritis a reversible chronic disease.
TL;DR: The joint-resident MSCs that play an essential local homeostatic role and regulate cell turn over and tissue repair are investigated, finding that they establish and maintain a local regenerative microenvironment.
Journal ArticleDOI
Bone marrow stromal cells from β -thalassemia patients have impaired hematopoietic supportive capacity
Stefania Crippa,Valeria Rossella,Annamaria Aprile,Laura Silvestri,Silvia Rivis,Samantha Scaramuzza,Stefania Pirroni,Maria Antonietta Avanzini,Luca Basso-Ricci,Raisa Jofra Hernandez,Marco Zecca,Sarah Marktel,Fabio Ciceri,Alessandro Aiuti,Giuliana Ferrari,Maria Ester Bernardo +15 more
TL;DR: An impairment in the mesenchymal compartment of BT BM niche is suggested and the need for novel strategies to target the niche to reduce IO and oxidative stress before transplantation is highlighted.
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The mechanisms of pathological extramedullary hematopoiesis in diseases.
TL;DR: A deeper understanding of the mechanism of pathological EMH may be conducive to the development of therapies against the pathological processes that induce EMH, and the recent progress of research on the cellular and molecular mechanisms is reviewed.
References
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Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Rafael A. Irizarry,Bridget G. Hobbs,Francois Collin,Yasmin Beazer-Barclay,Kristen J. Antonellis,Uwe Scherf,Terence P. Speed +6 more
TL;DR: There is no obvious downside to using RMA and attaching a standard error (SE) to this quantity using a linear model which removes probe-specific affinities, and the exploratory data analyses of the probe level data motivate a new summary measure that is a robust multi-array average (RMA) of background-adjusted, normalized, and log-transformed PM values.
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Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
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Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
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Osteoblastic cells regulate the haematopoietic stem cell niche
Laura M. Calvi,Gregor B. Adams,Kathryn W. Weibrecht,Jonathan M. Weber,David P. Olson,M. C. Knight,Roderick P. Martin,Ernestina Schipani,P. Divieti,F. R. Bringhurst,Laurie A. Milner,Henry M. Kronenberg,David T. Scadden +12 more
TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
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SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
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