Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
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TLDR
It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.About:
This article is published in Cell.The article was published on 2007-10-19 and is currently open access. It has received 2093 citations till now. The article focuses on the topics: Hematopoietic stem cell niche & Stromal cell.read more
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Journal ArticleDOI
A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more
TL;DR: Blood vessel walls harbor a reserve of progenitor cells that may be integral to the origin of the elusive MSCs and other related adult stem cells.
Journal ArticleDOI
Mesenchymal stem cells in health and disease
TL;DR: The targets and mechanisms of M SC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches are discussed.
Journal ArticleDOI
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
Simón Méndez-Ferrer,Tatyana V. Michurina,Francesca Ferraro,Amin R. Mazloom,Ben D. MacArthur,Ben D. MacArthur,Sergio A. Lira,David T. Scadden,Avi Ma'ayan,Grigori Enikolopov,Paul S. Frenette,Paul S. Frenette +11 more
TL;DR: It is demonstrated that mesenchymal stem cells (MSCs), identified using nestin expression, constitute an essential HSC niche component and are indicative of a unique niche in the bone marrow made of heterotypic stem-cell pairs.
Journal ArticleDOI
The bone marrow niche for haematopoietic stem cells
TL;DR: The haematopoietic stem cell niche remains incompletely defined and beset by competing models, and outstanding questions concern the cellular complexity of the niche, the role of the endosteum and functional heterogeneity among perivascular microenvironments.
Journal ArticleDOI
Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life
TL;DR: Niches are local tissue microenvironments that maintain and regulate stem cells that are key to the regulation of homeostasis and likely contribute to aging and tumorigenesis when altered during adulthood.
References
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Book ChapterDOI
Stromal mechanisms of bone marrow: cloning in vitro and retransplantation in vivo.
TL;DR: The effect of local differentiation factors is manifested, in particular, during formation of hemopoietic colonies in irradiated recipient-mice, and the development of myeloid precursors is inhibited while they are still included in the erythroid colonies whereas theDevelopment of erystroid precursor is suppressed in the myeloids colonies.
Journal ArticleDOI
Association of alkaline-phosphatase-positive reticulum cells in bone marrow with granulocytic precursors.
H Westen,D F Bainton +1 more
TL;DR: It is speculated that the alkaline-phosphatase- positive reticulum cell (Al-RC) are mesenchymal stromal cells necessary for granulocytic differentiation in bone marrow.
Journal ArticleDOI
Molecular Cloning and Characterization of Mouse TIE and TEK Receptor Tyrosine Kinase Genes and Their Expression in Hematopoietic Stem Cells
TL;DR: Characterization of two novel genes of their full-length cDNA sequences revealed that they were mouse homologues of the endothelial cell RTK genes, TIE and TEK, which shared a unique structural property of coexistent immunoglobulin-like domain, epidermal growth factor-like repeats, and fibronectin type III repeats in their extracellular domains.
Journal ArticleDOI
Reproduction of human fibrous dysplasia of bone in immunocompromised mice by transplanted mosaics of normal and Gsalpha-mutated skeletal progenitor cells.
Paolo Bianco,Sergei A. Kuznetsov,Mara Riminucci,Larry W. Fisher,Allen M. Spiegel,Pamela Gehron Robey +5 more
TL;DR: Results provide experimental evidence for the necessity of both normal and mutant cells in the development of McCune-Albright Syndrome fibrous dysplastic lesions in bone.
Book
Handbook of stem cells
Robert Lanza,John D. Gearhart,Brigid L.M. Hogan,Douglas A. Melton,Roger Pedersen,James A. Thomson,Mike West +6 more
TL;DR: This work contains contributions from the world's experts in stem cell research to provide a description of the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations as well as the latest information of what is known about each specific organ system.
Related Papers (5)
A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more