Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
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TLDR
It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.About:
This article is published in Cell.The article was published on 2007-10-19 and is currently open access. It has received 2093 citations till now. The article focuses on the topics: Hematopoietic stem cell niche & Stromal cell.read more
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PDGF in bone formation and regeneration: new insights into a novel mechanism involving MSCs.
Arnold I. Caplan,Diego Correa +1 more
TL;DR: This thesis explains how PDGF functions as a powerful therapeutic agent for bone formation and repair by suggesting that it could function at sites of injury to mobilize the pericytes from their abluminal location, stimulate mitotic expansion of these cells and help organize them.
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Engineering of a functional bone organ through endochondral ossification.
Celeste Scotti,Elia Piccinini,Hitoshi Takizawa,Atanas Todorov,Paul Bourgine,Adam Papadimitropoulos,Andrea Barbero,Markus G. Manz,Ivan Martin +8 more
TL;DR: The generation by appropriately instructed hMSC of an ectopic “bone organ” with a size, structure, and functionality comparable to native bones is reported, providing a model useful for fundamental and translational studies of bone morphogenesis and regeneration, as well as for the controlled manipulation of hematopoietic stem cell niches in physiology and pathology.
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Perivascular cells for regenerative medicine
TL;DR: Using purified perivascular cells instead of MSC may bring higher benefits to regenerative medicine, including the possibility, for the first time, to use these cells uncultured.
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Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs.
Ling Ye,Ling Ye,Zhipeng Fan,Bo Yu,Jia Chang,Khalid Al Hezaimi,Xuedong Zhou,No-Hee Park,Cun-Yu Wang +8 more
TL;DR: It is shown that the histone demethylases KDM4B and KDM6B play critical roles in osteogenic commitment of MSCs by removing H3K9me3 and H3k27me3, and may present as therapeutic targets for controlling MSC fate choices and lead to clues for new treatment in metabolic bone diseases such as osteoporosis.
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Regulation of hematopoietic stem cells by bone marrow stromal cells
Bryan A. Anthony,Daniel C. Link +1 more
TL;DR: The complex and diverse stromal cell populations that reside in the bone marrow are reviewed and recent data suggesting that perivascular chemokine CXC ligand (CXCL)12-expressing mesenchymal progenitors and endothelial cells are key cellular components of the stem cell niche in theBone marrow are highlighted.
References
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Journal ArticleDOI
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Rafael A. Irizarry,Bridget G. Hobbs,Francois Collin,Yasmin Beazer-Barclay,Kristen J. Antonellis,Uwe Scherf,Terence P. Speed +6 more
TL;DR: There is no obvious downside to using RMA and attaching a standard error (SE) to this quantity using a linear model which removes probe-specific affinities, and the exploratory data analyses of the probe level data motivate a new summary measure that is a robust multi-array average (RMA) of background-adjusted, normalized, and log-transformed PM values.
Journal ArticleDOI
Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
Journal ArticleDOI
Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
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Osteoblastic cells regulate the haematopoietic stem cell niche
Laura M. Calvi,Gregor B. Adams,Kathryn W. Weibrecht,Jonathan M. Weber,David P. Olson,M. C. Knight,Roderick P. Martin,Ernestina Schipani,P. Divieti,F. R. Bringhurst,Laurie A. Milner,Henry M. Kronenberg,David T. Scadden +12 more
TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
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SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
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A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more