Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
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TLDR
It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.About:
This article is published in Cell.The article was published on 2007-10-19 and is currently open access. It has received 2093 citations till now. The article focuses on the topics: Hematopoietic stem cell niche & Stromal cell.read more
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Immune modulation by mesenchymal stem cells
TL;DR: By choosing MSC tissue origin, cell dose, administration route, and treatment schedule, all the potential side effects related to MSC use, including tumor growth enhancement, have to be well considered to maximize the benefits of MSC-dependent immune regulation without significant risks for the patients.
Journal ArticleDOI
Characterization of bone marrow-derived mesenchymal stem cells in aging
TL;DR: This article focuses on bone marrow mesenchymal stem cells, which are unique compared to other stem cells due to their support of hematopoietic cells in addition to contributing to bone formation, and potential approaches to optimize the performance of aged BMSCs.
Journal ArticleDOI
Nestin-expressing progenitor cells: function, identity and therapeutic implications.
Aurora Bernal,Lorena Arranz +1 more
TL;DR: The current knowledge on the role of Nestin in essential stem cell functions, including self-renewal/proliferation, differentiation and migration, in the context of the cytoskeleton is presented.
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cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo
Ramakrishnaiah Siddappa,Anton C.M. Martens,Joyce Doorn,Anouk Leusink,Cristina Olivo,Ruud Licht,Linda van Rijn,Claudia Gaspar,Riccardo Fodde,Frank Janssen,Clemens van Blitterswijk,Jan de Boer +11 more
TL;DR: It is reported that activation of protein kinase A elicits an immediate response through induction of genes such as ID2 and FosB, followed by sustained secretion of bone-related cytokines, which results in robust in vivo bone formation by hMSCs derived from orthopedic patients.
Journal ArticleDOI
In vivo fate mapping identifies mesenchymal progenitor cells.
Danka Grčević,Slavica Pejda,Slavica Pejda,Brya G. Matthews,Dario Repić,Dario Repić,Liping Wang,Haitao Li,Mark S. Kronenberg,Xi Jiang,Peter Maye,Douglas J. Adams,David W. Rowe,Hector L. Aguila,Ivo Kalajzic +14 more
TL;DR: In this paper, a smooth muscle α-actin promoter (αSMA)-directed Cre transgene was used to identify mesenchymal progenitors of adult bone tissue.
References
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Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Rafael A. Irizarry,Bridget G. Hobbs,Francois Collin,Yasmin Beazer-Barclay,Kristen J. Antonellis,Uwe Scherf,Terence P. Speed +6 more
TL;DR: There is no obvious downside to using RMA and attaching a standard error (SE) to this quantity using a linear model which removes probe-specific affinities, and the exploratory data analyses of the probe level data motivate a new summary measure that is a robust multi-array average (RMA) of background-adjusted, normalized, and log-transformed PM values.
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Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
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Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
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Osteoblastic cells regulate the haematopoietic stem cell niche
Laura M. Calvi,Gregor B. Adams,Kathryn W. Weibrecht,Jonathan M. Weber,David P. Olson,M. C. Knight,Roderick P. Martin,Ernestina Schipani,P. Divieti,F. R. Bringhurst,Laurie A. Milner,Henry M. Kronenberg,David T. Scadden +12 more
TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
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SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
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A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more