Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
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TLDR
It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.About:
This article is published in Cell.The article was published on 2007-10-19 and is currently open access. It has received 2093 citations till now. The article focuses on the topics: Hematopoietic stem cell niche & Stromal cell.read more
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Msx2 Exerts Bone Anabolism via Canonical Wnt Signaling
TL;DR: Bone anabolism is exerted in part by reducing Dkk1 expression and enhancing Wnt signaling, thus promoting osteogenic differentiation of skeletal progenitors, and RNA interference-mediated knockdown of Wnt7a, Wnt 7b, and LRP6 significantly reduced Msx2-induced alkaline phosphatase.
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Mesenchymal stromal cells in cancer: a review of their immunomodulatory functions and dual effects on tumor progression
Sabine Galland,Ivan Stamenkovic +1 more
TL;DR: This review summarizes the current understanding of MSC involvement in tumor development and highlights the mechanistic underpinnings of their implication in tumor growth and progression.
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Engineering a humanized bone organ model in mice to study bone metastases
Laure Martine,Boris Michael Holzapfel,Boris Michael Holzapfel,Jacqui A. McGovern,Ferdinand Wagner,Ferdinand Wagner,Ferdinand Wagner,Verena M.C. Quent,Verena M.C. Quent,Parisa Hesami,Felix M. Wunner,Cedryck Vaquette,Elena M. De-Juan-Pardo,Toby D. Brown,Bianca Nowlan,Dan Jing Wu,Dan Jing Wu,Cosmo Orlando Hutmacher,Davide Moi,Tatiana Oussenko,Elia Piccinini,Peter W. Zandstra,Roberta Mazzieri,Jean-Pierre Levesque,Paul D. Dalton,Paul D. Dalton,Anna Taubenberger,Anna Taubenberger,Dietmar W. Hutmacher,Dietmar W. Hutmacher,Dietmar W. Hutmacher +30 more
TL;DR: In this paper, the authors developed a protocol to engineer humanized bone within immunodeficient hosts, which can be adapted to study the interactions between human cancer cells and a humanised bone microenvironment in vivo.
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Mesenchymal stem cell treatment is associated with decreased perfusate concentration of interleukin-8 during ex vivo perfusion of donor lungs after 18-hour preservation
Pierre Mordant,D. Nakajima,R. Kalaf,Ilker Iskender,L. Maahs,P. Behrens,R. Coutinho,Rohin K. Iyer,John E. Davies,Marcelo Cypel,Mingyao Liu,Thomas K. Waddell,Shaf Keshavjee +12 more
TL;DR: Intravascular delivery of 150 × 106 MSCs showed preferred outcome compared with intrabronchial delivery to damaged lungs perfused ex vivo and was well tolerated and associated with an increased concentration of human VEGF in the lung tissue and a decreased concentration of pig IL-8 in the perfusate.
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Concise Review: Current Concepts in Bone Marrow Microenvironmental Regulation of Hematopoietic Stem and Progenitor Cells
Julianne Smith,Laura M. Calvi +1 more
TL;DR: Some of the key findings defining these regulatory interactions are explored in this concise review, with special emphasis on potential translational applications.
References
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Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Rafael A. Irizarry,Bridget G. Hobbs,Francois Collin,Yasmin Beazer-Barclay,Kristen J. Antonellis,Uwe Scherf,Terence P. Speed +6 more
TL;DR: There is no obvious downside to using RMA and attaching a standard error (SE) to this quantity using a linear model which removes probe-specific affinities, and the exploratory data analyses of the probe level data motivate a new summary measure that is a robust multi-array average (RMA) of background-adjusted, normalized, and log-transformed PM values.
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Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
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Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
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Osteoblastic cells regulate the haematopoietic stem cell niche
Laura M. Calvi,Gregor B. Adams,Kathryn W. Weibrecht,Jonathan M. Weber,David P. Olson,M. C. Knight,Roderick P. Martin,Ernestina Schipani,P. Divieti,F. R. Bringhurst,Laurie A. Milner,Henry M. Kronenberg,David T. Scadden +12 more
TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
Journal ArticleDOI
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
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A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more