Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
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TLDR
It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.About:
This article is published in Cell.The article was published on 2007-10-19 and is currently open access. It has received 2093 citations till now. The article focuses on the topics: Hematopoietic stem cell niche & Stromal cell.read more
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CD36 Is a Marker of Human Adipocyte Progenitors with Pronounced Adipogenic and Triglyceride Accumulation Potential.
Hui Gao,Fanny Volat,Lakshmi Sandhow,Jean Galitzky,Thuy Nguyen,David Estève,Gaby Åström,Niklas Mejhert,Séverine Ledoux,Claire Thalamas,Peter Arner,Jean-Claude Guillemot,Hong Qian,Mikael Rydén,Anne Bouloumié +14 more
TL;DR: It is concluded that CD36 marks APs with pronounced adipogenic potential, most probably by facilitating lipid uptake, which may be of value in developing human adipocyte cell clones and possibly in linking regional variations in adipogenesis to metabolic phenotype.
Journal ArticleDOI
The Perivascular Niche and Self-Renewal of Stem Cells
Min Oh,Jacques E. Nör +1 more
TL;DR: It is postulate that signaling events that establish and/or stabilize the perivascular niche, particularly through the modulation of self-renewing factors, are key to the long-term success of regenerated tissues.
Journal ArticleDOI
Stem cell regulatory niches and their role in normal and malignant hematopoiesis.
Nadia Carlesso,Angelo A. Cardoso +1 more
TL;DR: Increasing insights into the cell–cell cross talk between the hematopoietic system and its microenvironment in the bone marrow, and in particular in the interplay of HSCs with their niche(s), should provide new tools for combinatorial therapies in bone marrow failure and bone marrow cancers.
Journal ArticleDOI
Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells.
Wuchen Yang,Dayong Guo,Marie A. Harris,Yong Cui,Jelica Gluhak-Heinrich,Junjie Wu,Xiao Dong Chen,Charles M. Skinner,Jeffry S. Nyman,James R. Edwards,Gregory R. Mundy,Alexander C. Lichtler,Barbara E. Kream,David W. Rowe,Ivo Kalajzic,Val David,Darryl L. Quarles,Demetri Villareal,Greg Scott,Manas K. Ray,Shiguang Liu,James F. Martin,Yuji Mishina,Stephen E. Harris +23 more
TL;DR: Critical roles of Bmp2 in osteoblasts and MSCs are a vital link between bone formation, vascularization and mesenchymal stem cells.
Journal ArticleDOI
Using mesenchymal stem cells as a therapy for bone regeneration and repairing
Jin Shao,Weiwei Zhang,Tieyi Yang +2 more
TL;DR: The recent developments in understanding the mechanism of MSCs action in bone regeneration and repairing are introduced.
References
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Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Rafael A. Irizarry,Bridget G. Hobbs,Francois Collin,Yasmin Beazer-Barclay,Kristen J. Antonellis,Uwe Scherf,Terence P. Speed +6 more
TL;DR: There is no obvious downside to using RMA and attaching a standard error (SE) to this quantity using a linear model which removes probe-specific affinities, and the exploratory data analyses of the probe level data motivate a new summary measure that is a robust multi-array average (RMA) of background-adjusted, normalized, and log-transformed PM values.
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Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
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Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
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Osteoblastic cells regulate the haematopoietic stem cell niche
Laura M. Calvi,Gregor B. Adams,Kathryn W. Weibrecht,Jonathan M. Weber,David P. Olson,M. C. Knight,Roderick P. Martin,Ernestina Schipani,P. Divieti,F. R. Bringhurst,Laurie A. Milner,Henry M. Kronenberg,David T. Scadden +12 more
TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
Journal ArticleDOI
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
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A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more