Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
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TLDR
It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.About:
This article is published in Cell.The article was published on 2007-10-19 and is currently open access. It has received 2093 citations till now. The article focuses on the topics: Hematopoietic stem cell niche & Stromal cell.read more
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Book ChapterDOI
Development of the Skeleton
TL;DR: This chapter considers the strategies used to pattern the skeleton and the processes of endochondral and intramembranous bone formation during development, and considers the signaling systems, transcription factors, and cell types that coordinate formation of the skeleton.
Journal ArticleDOI
Effect of three-dimensional culture and incubator gas concentration on phenotype and differentiation capability of human mesenchymal stem cells.
Tommy A. Karlsen,Peyman Mirtaheri,Peyman Mirtaheri,Aboulghassem Shahdadfar,Yngvar Fløisand,Jan E. Brinchmann +5 more
TL;DR: 3D culture alone increased the expression of some molecules involved in osteogenic and adipogenic differentiation, and induced chondrogenic differentiation in hBM‐MSC, showing that the hyperoxia of room air is not detrimental to hBM-MSC proliferation, differentiation, or phenotype.
Journal ArticleDOI
Different Angiogenic Potentials of Mesenchymal Stem Cells Derived from Umbilical Artery, Umbilical Vein, and Wharton's Jelly.
Lu Xu,Jianjun Zhou,Jingyu Liu,Yong Liu,Lei Wang,Ruiwei Jiang,Zhenyu Diao,Guijun Yan,Bruno Péault,Haixiang Sun,Lijun Ding +10 more
TL;DR: UCA-PSCs are promising cell populations for clinical use in ischemic diseases and had the highest expression of the Notch ligand Jagged1 (JAG1), which is crucial for blood vessel maturation.
Journal ArticleDOI
Drosha regulates hMSCs cell cycle progression through a miRNA independent mechanism
TL;DR: Results indicate that Drosha modifies hMSCs proliferation through a miRNA independent mechanism, potentially by regulating rRNA processing.
Book ChapterDOI
Biological differences between native and cultured mesenchymal stem cells: implications for therapies.
Elena Jones,Richard Schäfer +1 more
TL;DR: The understanding of the biology of MSCs in their native niches in the bone marrow could lead to future developments in the treatment of hematological diseases such as multiple myeloma and graft-versus-host and other diseases.
References
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Journal ArticleDOI
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Rafael A. Irizarry,Bridget G. Hobbs,Francois Collin,Yasmin Beazer-Barclay,Kristen J. Antonellis,Uwe Scherf,Terence P. Speed +6 more
TL;DR: There is no obvious downside to using RMA and attaching a standard error (SE) to this quantity using a linear model which removes probe-specific affinities, and the exploratory data analyses of the probe level data motivate a new summary measure that is a robust multi-array average (RMA) of background-adjusted, normalized, and log-transformed PM values.
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Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
Journal ArticleDOI
Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
Journal ArticleDOI
Osteoblastic cells regulate the haematopoietic stem cell niche
Laura M. Calvi,Gregor B. Adams,Kathryn W. Weibrecht,Jonathan M. Weber,David P. Olson,M. C. Knight,Roderick P. Martin,Ernestina Schipani,P. Divieti,F. R. Bringhurst,Laurie A. Milner,Henry M. Kronenberg,David T. Scadden +12 more
TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
Journal ArticleDOI
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
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A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more