Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
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TLDR
It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.About:
This article is published in Cell.The article was published on 2007-10-19 and is currently open access. It has received 2093 citations till now. The article focuses on the topics: Hematopoietic stem cell niche & Stromal cell.read more
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CD146 + mesenchymal stem cells display greater therapeutic potential than CD146 – cells for treating collagen-induced arthritis in mice
Cheng-Chi Wu,Cheng-Chi Wu,Fei-Lan Liu,Huey-Kang Sytwu,Chang-Youh Tsai,Deh-Ming Chang,Deh-Ming Chang +6 more
TL;DR: It is suggested that CD146+ cells have greater potency than CD146– cells for cartilage protection and can suppress Th17 cell activation and suggest a potential therapeutic application for CD 146+ cells in treating inflammatory arthritis.
Journal ArticleDOI
Fibroblast growth factor 2 and platelet-derived growth factor, but not platelet lysate, induce proliferation-dependent, functional class II major histocompatibility complex antigen in human mesenchymal stem cells.
Chiara Bocelli-Tyndall,Paul Zajac,Nunzia Di Maggio,Emanuele Trella,Federica Benvenuto,Giandomenica Iezzi,Arnaud Scherberich,Andrea Barbero,Stefan Schaeren,Vito Pistoia,Giulio C. Spagnoli,Mirko Vukcevic,Ivan Martin,Alan Tyndall +13 more
TL;DR: The induction of functional HLA-DR in proliferating progenitor MSCs is a property of human M SCs that have been expanded with mitogenic growth factors and needs to be taken into account when expanding MSC’s for use in in vivo applications.
Journal ArticleDOI
The Vascular Stem Cell Niche
Maria Victoria Gómez-Gaviro,Robin Lovell-Badge,Francisco Fernández-Avilés,Enrique Lara-Pezzi +3 more
TL;DR: This review focuses on the regulation of stem and progenitor cells in different adult niches by blood vessels and the few mechanisms that are known to mediate this interaction.
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Mesenchymal Stem Cells and Potential Applications in Treating Ocular Disease
Aaron W. Joe,Kevin Gregory-Evans +1 more
TL;DR: Clinical roles for MSC therapy in neuroprotection and immune suppression are likely to emerge, and MSC-based molecular therapy could overcome some of the difficulties of long-term drug delivery to tissues, such as the eye, which are relatively inaccessible to systemic delivery.
Journal ArticleDOI
Distinctive contact between CD34+ hematopoietic progenitors and CXCL12+ CD271+ mesenchymal stromal cells in benign and myelodysplastic bone marrow
TL;DR: The preservation of direct CD271+ MSC/CD34+ HSPC contact across benign and neoplastic marrow suggests a physiologically important role for the CD271- MSC-HSPC relationship and possible abnormal exposure of CD34- HSPCs to increased MSC CXCL12 expression in MDS.
References
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Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Rafael A. Irizarry,Bridget G. Hobbs,Francois Collin,Yasmin Beazer-Barclay,Kristen J. Antonellis,Uwe Scherf,Terence P. Speed +6 more
TL;DR: There is no obvious downside to using RMA and attaching a standard error (SE) to this quantity using a linear model which removes probe-specific affinities, and the exploratory data analyses of the probe level data motivate a new summary measure that is a robust multi-array average (RMA) of background-adjusted, normalized, and log-transformed PM values.
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Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
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Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
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Osteoblastic cells regulate the haematopoietic stem cell niche
Laura M. Calvi,Gregor B. Adams,Kathryn W. Weibrecht,Jonathan M. Weber,David P. Olson,M. C. Knight,Roderick P. Martin,Ernestina Schipani,P. Divieti,F. R. Bringhurst,Laurie A. Milner,Henry M. Kronenberg,David T. Scadden +12 more
TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
Journal ArticleDOI
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
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A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more