Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
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TLDR
It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.About:
This article is published in Cell.The article was published on 2007-10-19 and is currently open access. It has received 2093 citations till now. The article focuses on the topics: Hematopoietic stem cell niche & Stromal cell.read more
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Not All Pericytes Are Born Equal: Pericytes from Human Adult Tissues Present Different Differentiation Properties.
TL;DR: Current knowledge on human PCs is presented and recent data on the differentiation properties of PCs isolated from different adult tissues are highlighted, suggesting that the multipotent mesenchymal ability of PCs might be restrained within different tissues, likely depending on the specific cell renewal and repair requirements of each tissue.
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Follicular lymphoma triggers phenotypic and functional remodeling of the human lymphoid stromal cell landscape
Frédéric Mourcin,Léa Verdière,David Roulois,Rada Amin,Claire Lamaison,Vonick Sibut,Brice Thamphya,Céline Pangault,Céline Monvoisin,Sarah Huet,Marine Seffals,Sylvain Baulande,Fatima Mechta-Grigoriou,Patricia Legoix,Delphine Rossille,Marion Guirriec,Simon Léonard,Guillaume Cartron,Gilles Salles,Thierry Fest,Karin Tarte +20 more
TL;DR: In this paper, the effect of B cell stimuli on lymphoid stromal cells (LSCs) in follicular lymphoma (FL) was examined by combining flow cytometry, in situ imaging, RNA sequencing and functional assays, defining three distinct human LSC subsets.
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Fractionated human adipose tissue as a native biomaterial for the generation of a bone organ by endochondral ossification.
Julien Guerrero,Sebastien Pigeot,Judith Müller,Dirk J. Schaefer,Ivan Martin,Arnaud Scherberich,Arnaud Scherberich +6 more
TL;DR: It is demonstrated that adult human adipose tissue used as a native construct can generate a bone organ by endochondral ossification and the present paradigm proposes to exploit physiological niches in order to better maintain the functionality of cells during their in vitro expansion.
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Role of Prx1-expressing skeletal cells and Prx1-expression in fracture repair
TL;DR: The identification of fracture-induced perivascular Prx1+ cells and regulation of Prx 1's expression by BMP2 and in turn by CXCL12 in the orchestration of fracture repair, highlights a pathway in which to investigate defective mechanisms and therapeutic targets for fracture non-union.
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Regulation of Bone Marrow Angiogenesis by Osteoblasts during Bone Development and Homeostasis
TL;DR: Current knowledge about the role of the HIF signaling pathway in controlling bone development and homeostasis, and especially in regulating the crosstalk between osteoblasts, progenitor cells, and bone marrow blood vessels is summarized.
References
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Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Rafael A. Irizarry,Bridget G. Hobbs,Francois Collin,Yasmin Beazer-Barclay,Kristen J. Antonellis,Uwe Scherf,Terence P. Speed +6 more
TL;DR: There is no obvious downside to using RMA and attaching a standard error (SE) to this quantity using a linear model which removes probe-specific affinities, and the exploratory data analyses of the probe level data motivate a new summary measure that is a robust multi-array average (RMA) of background-adjusted, normalized, and log-transformed PM values.
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Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
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Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
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Osteoblastic cells regulate the haematopoietic stem cell niche
Laura M. Calvi,Gregor B. Adams,Kathryn W. Weibrecht,Jonathan M. Weber,David P. Olson,M. C. Knight,Roderick P. Martin,Ernestina Schipani,P. Divieti,F. R. Bringhurst,Laurie A. Milner,Henry M. Kronenberg,David T. Scadden +12 more
TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
Journal ArticleDOI
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
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A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more