Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
Reads0
Chats0
TLDR
It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.About:
This article is published in Cell.The article was published on 2007-10-19 and is currently open access. It has received 2093 citations till now. The article focuses on the topics: Hematopoietic stem cell niche & Stromal cell.read more
Citations
More filters
Journal ArticleDOI
Regional specialization and fate specification of bone stromal cells in skeletal development.
Kishor K. Sivaraj,Hyun-Woo Jeong,Backialakshmi Dharmalingam,Dagmar Zeuschner,Susanne Adams,Michael Potente,Ralf H. Adams +6 more
TL;DR: In this paper, the lineage relationship between BMSC subsets and their regulation by intrinsic and extrinsic factors are not well understood, and it is shown with mouse genetics, ex-vivo cell differentiation assays, and transcriptional profiling that BMSCs from metaphysis (mpMSCs) and diaphysis (dpMSCs), are fundamentally distinct.
Journal ArticleDOI
Characterization and immunosuppressive properties of mesenchymal stem cells from periapical lesions.
Jelena Đokić,Sergej Tomić,Snežana Cerović,Vera Todorovic,Rebeka Rudolf,Miodrag Čolić,Miodrag Čolić +6 more
TL;DR: The differentiation potential of PL-MSCs and their immunosuppressive/anti-inflammatory properties could be beneficial for the treatment of chronic periodontal diseases.
Journal ArticleDOI
Activation of the Pro-Oxidant PKCβII-p66Shc Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Patients With Diabetes With Critical Limb Ischemia.
Rosa Vono,Claudia Fuoco,Stefano Testa,Stefano Pirrò,Davide Maselli,David Ferland McCollough,Elena Sangalli,Gianfranco Pintus,Roberta Giordo,Giovanna Finzi,Fausto Sessa,Rosanna Cardani,Ambra Gotti,Sergio Losa,Gianni Cesareni,Roberto Rizzi,Claudia Bearzi,Stefano Cannata,Gaia Spinetti,Cesare Gargioli,Paolo Madeddu +20 more
TL;DR: Investigating whether and by which mechanism diabetes negatively impacts on functional properties of muscular pericytes (MPs), which are resident stem cells committed to reparative angiomyogenesis, suggests inhibition of the PKCβII-dependent p66Shc signaling pathway could represent a novel therapeutic approach for the promotion of muscle repair in individuals with diabetes.
Journal ArticleDOI
Osteoblast ontogeny and implications for bone pathology: an overview
TL;DR: The newly acquired knowledge of the ontogeny of osteoblasts will assist in unravelling the abnormalities taking place during their differentiation and will facilitate the prevention and/or treatment of bone diseases by therapy directed against altered molecules and mechanisms.
Journal ArticleDOI
Reporting Guidelines, Review of Methodological Standards, and Challenges Toward Harmonization in Bone Marrow Adiposity Research. Report of the Methodologies Working Group of the International Bone Marrow Adiposity Society.
Josefine Tratwal,Rossella Labella,Nathalie Bravenboer,Nathalie Bravenboer,Greet Kerckhofs,Greet Kerckhofs,Eleni Douni,Erica L. Scheller,Sammy Badr,Dimitrios C. Karampinos,Sarah Beck-Cormier,Biagio Palmisano,Antonella Poloni,María J. Moreno-Aliaga,Jackie A. Fretz,Matthew S. Rodeheffer,Parastoo Boroumand,Clifford J. Rosen,Mark C. Horowitz,Bram C. J. van der Eerden,Annegreet G Veldhuis-Vlug,Annegreet G Veldhuis-Vlug,Olaia Naveiras +22 more
TL;DR: A working group to evaluate methodologies in bone marrow adiposity research advocates for the harmonization of methodologies, the precise reporting of known confounding factors, and the identification of methods to modulate BMA independently from other tissues.
References
More filters
Journal ArticleDOI
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Rafael A. Irizarry,Bridget G. Hobbs,Francois Collin,Yasmin Beazer-Barclay,Kristen J. Antonellis,Uwe Scherf,Terence P. Speed +6 more
TL;DR: There is no obvious downside to using RMA and attaching a standard error (SE) to this quantity using a linear model which removes probe-specific affinities, and the exploratory data analyses of the probe level data motivate a new summary measure that is a robust multi-array average (RMA) of background-adjusted, normalized, and log-transformed PM values.
Journal ArticleDOI
Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
Journal ArticleDOI
Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
Journal ArticleDOI
Osteoblastic cells regulate the haematopoietic stem cell niche
Laura M. Calvi,Gregor B. Adams,Kathryn W. Weibrecht,Jonathan M. Weber,David P. Olson,M. C. Knight,Roderick P. Martin,Ernestina Schipani,P. Divieti,F. R. Bringhurst,Laurie A. Milner,Henry M. Kronenberg,David T. Scadden +12 more
TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
Journal ArticleDOI
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
Related Papers (5)
A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more