Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
Reads0
Chats0
TLDR
It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.About:
This article is published in Cell.The article was published on 2007-10-19 and is currently open access. It has received 2093 citations till now. The article focuses on the topics: Hematopoietic stem cell niche & Stromal cell.read more
Citations
More filters
Journal ArticleDOI
Cell Sources for Bone Tissue Engineering: Insights from Basic Science
TL;DR: In this article, the authors examine the mechanisms of endogenous cell recruitment during bone repair and compare the role of local versus systemic cell recruitment, and discuss how the normal repair process can help define efficacious cell sources for bone tissue engineering and improve their methods of delivery.
Journal ArticleDOI
Mesenchymal stem cells and their use in therapy: what has been achieved?
V.B. Fernández Vallone,M.A. Romaniuk,Hosoon Choi,Vivian Labovsky,J. Otaegui,Norma Alejandra Chasseing +5 more
TL;DR: The Mesenchymal and Tissue Stem Cell Committee of the International Society for Cellular Therapy proposed minimal criteria to define human MSCs, suggesting that they may be used as therapeutic tools in immune-mediated disorders.
Journal ArticleDOI
Superparamagnetic Iron Oxide Nanoparticles Labeling of Bone Marrow Stromal (Mesenchymal) Cells Does Not Affect Their “Stemness”
Arun Balakumaran,Edyta Pawelczyk,Jiaqiang Ren,Brian Sworder,Aneeka Chaudhry,Marianna Sabatino,David F. Stroncek,Joseph A. Frank,Pamela Gehron Robey +8 more
TL;DR: This study confirms that SPION labeling does not alter the differentiation potential of the subset of stem cells within BMSCs, and thus maintains the “stemness” of cells within the BMSC population in vivo.
Journal ArticleDOI
Mesenchymal stem cell-derived secretome and microvesicles as a cell-free therapeutics for neurodegenerative disorders
TL;DR: Investigations suggest that MSC secretome and microvesicles can recapitulate the beneficial effects as their cellular counterparts in tissue regeneration, and represent a promising candidate for a novel cell-free therapy for neurodegenerative diseases.
Journal ArticleDOI
BMP2 is essential for post natal osteogenesis but not for recruitment of osteogenic stem cells
Manish V. Bais,Nathan A. Wigner,Megan Young,Ryan Toholka,Dana T. Graves,Elise F. Morgan,Louis C. Gerstenfeld,Thomas A. Einhorn +7 more
TL;DR: The results demonstrate that in vivo BMP2 is a central morphogenetic regulator of post natal osteoprogenitor differentiation, but does not affect recruitment of progenitors to the osteoblastic lineage.
References
More filters
Journal ArticleDOI
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Rafael A. Irizarry,Bridget G. Hobbs,Francois Collin,Yasmin Beazer-Barclay,Kristen J. Antonellis,Uwe Scherf,Terence P. Speed +6 more
TL;DR: There is no obvious downside to using RMA and attaching a standard error (SE) to this quantity using a linear model which removes probe-specific affinities, and the exploratory data analyses of the probe level data motivate a new summary measure that is a robust multi-array average (RMA) of background-adjusted, normalized, and log-transformed PM values.
Journal ArticleDOI
Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
Journal ArticleDOI
Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
Journal ArticleDOI
Osteoblastic cells regulate the haematopoietic stem cell niche
Laura M. Calvi,Gregor B. Adams,Kathryn W. Weibrecht,Jonathan M. Weber,David P. Olson,M. C. Knight,Roderick P. Martin,Ernestina Schipani,P. Divieti,F. R. Bringhurst,Laurie A. Milner,Henry M. Kronenberg,David T. Scadden +12 more
TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
Journal ArticleDOI
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
Related Papers (5)
A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more