Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
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TLDR
It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.About:
This article is published in Cell.The article was published on 2007-10-19 and is currently open access. It has received 2093 citations till now. The article focuses on the topics: Hematopoietic stem cell niche & Stromal cell.read more
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A Subpopulation of Stromal Cells Controls Cancer Cell Homing to the Bone Marrow.
Stephanie Rossnagl,Stephanie Rossnagl,Hiba Ghura,Hiba Ghura,Christopher Groth,Christopher Groth,Eva Altrock,Eva Altrock,Franz Jakob,Sarah Schott,Pauline Wimberger,Theresa Link,Jan Dominik Kuhlmann,Arnulf Stenzl,Jörg Hennenlotter,T. Todenhöfer,Markus Rojewski,Karen Bieback,Inaam A. Nakchbandi,Inaam A. Nakchbandi +19 more
TL;DR: The findings establish an inverse relationship between a subpopulation of mesenchymal stromal cells and cancer cells in the bone marrow, which could prove useful in determining the risk of metastatic disease, and its manipulation might offer a new possibility for diminishing bone metastasis formation.
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Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges.
Vadims Parfejevs,Krizia Sagini,Arturs Buss,Kristine Sobolevska,Alicia Llorente,Una Riekstina,Arturs Abols +6 more
TL;DR: The aim of the review is to summarise current knowledge of adult SC-EV application in cancer treatment and to emphasise future opportunities and challenges incancer treatment.
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Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors
TL;DR: A review of the identification, isolation, and characterization of human blood-vessel-derived stem cells (hBVSCs) can be found in this article, where the three precursor subsets, myogenic endothelial cells (MECs), pericytes (PCs), and adventitial cells (ACs), are located, respectively, in the three structural tiers of typical blood vessels: intima, media, and adventitia.
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Characterization of Different Sources of Human MSCs Expanded in Serum-Free Conditions with Quantification of Chondrogenic Induction in 3D.
Hugo Fabre,Maxime Ducret,Olivier Degoul,Jonathan Rodriguez,Emeline Perrier-Groult,Elisabeth Aubert-Foucher,Marielle Pasdeloup,Céline Auxenfans,Colin P. McGuckin,Nico Forraz,Frédéric Mallein-Gerin +10 more
TL;DR: This work represents the first comparison of detailed immunophenotypic analysis and chondrogenic differentiation potential of human BM-, WJ-, DP-, and AT-MSCs performed under the same serum-free conditions, from their isolation to their induction.
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Standardised Nomenclature, Abbreviations, and Units for the Study of Bone Marrow Adiposity: Report of the Nomenclature Working Group of the International Bone Marrow Adiposity Society.
Nathalie Bravenboer,Miriam A. Bredella,Christophe Chauveau,Alessandro Corsi,Eleni Douni,William F. Ferris,Mara Riminucci,Pamela Gehron Robey,Shanti Rojas-Sutterlin,Clifford J. Rosen,Tim J. Schulz,William P. Cawthorn +11 more
TL;DR: The standard nomenclature proposed in this article should be followed for all communications of results related to BMA, and will allow for better interactions both inside and outside of this emerging scientific community.
References
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Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Rafael A. Irizarry,Bridget G. Hobbs,Francois Collin,Yasmin Beazer-Barclay,Kristen J. Antonellis,Uwe Scherf,Terence P. Speed +6 more
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Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
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Osteoblastic cells regulate the haematopoietic stem cell niche
Laura M. Calvi,Gregor B. Adams,Kathryn W. Weibrecht,Jonathan M. Weber,David P. Olson,M. C. Knight,Roderick P. Martin,Ernestina Schipani,P. Divieti,F. R. Bringhurst,Laurie A. Milner,Henry M. Kronenberg,David T. Scadden +12 more
TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
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SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
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A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more