Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
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TLDR
It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.About:
This article is published in Cell.The article was published on 2007-10-19 and is currently open access. It has received 2093 citations till now. The article focuses on the topics: Hematopoietic stem cell niche & Stromal cell.read more
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Biological functions of mesenchymal stem cells and clinical implications
Abderrahim Naji,Masamitsu Eitoku,Benoit Favier,Frédéric Deschaseaux,Nathalie Rouas-Freiss,Narufumi Suganuma +5 more
TL;DR: The fundamental and advanced concepts of MSC biological features are outlined and the biological functions of M SCs in their basic and translational aspects in therapy for degenerative and/or inflammatory diseases are underlined.
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Isolation of mouse mesenchymal stem cells on the basis of expression of Sca-1 and PDGFR-α.
Diarmaid D. Houlihan,Yo Mabuchi,Yo Mabuchi,Satoru Morikawa,Kunimichi Niibe,Daisuke Araki,Sadafumi Suzuki,Hideyuki Okano,Yumi Matsuzaki +8 more
TL;DR: This protocol to isolate PDGFR-α+Sca-1+ (PαS) MSCs using flow cytometry avoids cellular contamination that can complicate other methods and has augmented growth potential and robust tri-lineage differentiation compared with standard culture-selected M SCs.
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Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs)
TL;DR: Conclusions/perspectives are drawn on why is administration of MSCs beneficial?
Journal ArticleDOI
Role of Pericytes in Skeletal Muscle Regeneration and Fat Accumulation
Alexander Birbrair,Tan Zhang,Zhong-Min Wang,María Laura Messi,Grigori Enikolopov,Akiva Mintz,Osvaldo Delbono +6 more
TL;DR: The results suggest that type-1 and type-2 pericytes contribute to successful muscle regeneration which results from a balance of myogenic and nonmyogenic cells activation.
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Natural history of mesenchymal stem cells, from vessel walls to culture vessels
Iain R. Murray,Christopher C. West,Winters R. Hardy,Aaron W. James,Tea Soon Park,Alan Nguyen,Tulyapruek Tawonsawatruk,Lorenza Lazzari,Chia Soo,Bruno Péault,Bruno Péault +10 more
TL;DR: A growing body of experimental data is currently paving the way to the medical usage of autologous sorted perivascular cells for indications in which MSCs have been previously contemplated or actually used, such as bone regeneration and cardiovascular tissue repair.
References
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Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Rafael A. Irizarry,Bridget G. Hobbs,Francois Collin,Yasmin Beazer-Barclay,Kristen J. Antonellis,Uwe Scherf,Terence P. Speed +6 more
TL;DR: There is no obvious downside to using RMA and attaching a standard error (SE) to this quantity using a linear model which removes probe-specific affinities, and the exploratory data analyses of the probe level data motivate a new summary measure that is a robust multi-array average (RMA) of background-adjusted, normalized, and log-transformed PM values.
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Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
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Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
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Osteoblastic cells regulate the haematopoietic stem cell niche
Laura M. Calvi,Gregor B. Adams,Kathryn W. Weibrecht,Jonathan M. Weber,David P. Olson,M. C. Knight,Roderick P. Martin,Ernestina Schipani,P. Divieti,F. R. Bringhurst,Laurie A. Milner,Henry M. Kronenberg,David T. Scadden +12 more
TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
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SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
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A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more