Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
Reads0
Chats0
TLDR
It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.About:
This article is published in Cell.The article was published on 2007-10-19 and is currently open access. It has received 2093 citations till now. The article focuses on the topics: Hematopoietic stem cell niche & Stromal cell.read more
Citations
More filters
Journal ArticleDOI
Fibroblast Growth Factor-2 Stimulates the Proliferation of Mesenchyme-Derived Progenitor Cells From Aging Mouse and Human Bone
Guomin Ou,Lyndon F. Charles,Seth Matton,Craig M. Rodner,Marja M. Hurley,Liisa T. Kuhn,Gloria Gronowicz +6 more
TL;DR: FGF-2 was shown to significantly stimulate, in a dose-dependent manner, proliferation of mesenchyme-derived progenitor cells from bones of young and old mouse and humans, and may have therapeutic potential for stimulating osteoblast progenitors in aging.
Journal ArticleDOI
Loss of androgen receptor promotes adipogenesis but suppresses osteogenesis in bone marrow stromal cells
Chiung-Kuei Huang,Kuo-Pao Lai,Jie Luo,Meng-Yin Tsai,Hong-Yo Kang,Yuhchyau Chen,Soo Ok Lee,Chawnshang Chang,Chawnshang Chang +8 more
TL;DR: It is demonstrated that loss of the androgen receptor (AR) in BMSCs suppressed osteogenesis but promoted adipogenesis, and suggested that AR-mediated changes in IGFBP3 might modulate the IGF-Akt axis to regulate adipogenesis in B MSCs.
Journal ArticleDOI
Endothelium-derived stromal cells contribute to hematopoietic bone marrow niche formation
Keane Jared Guillaume Kenswil,Paola Pisterzi,Gonzalo Sanchez-Duffhues,Claire van Dijk,Andrea Lolli,Callie Knuth,Byambasuren Vanchin,Adrian Christopher Jaramillo,Remco Hoogenboezem,Mathijs A. Sanders,Jacqueline Feyen,Tom Cupedo,Ivan G. Costa,Ronghui Li,Eric M.J. Bindels,Kirsten Lodder,Bianca Blom,Pieter K. Bos,Marie-José Goumans,Peter ten Dijke,Eric Farrell,Guido Krenning,Marc H.G.P. Raaijmakers +22 more
TL;DR: In this paper, the authors identify rare LNGFR(+) cells in human fetal and regenerative bone marrow that co-express endothelial and stromal markers and reveal the generation of tissue-forming BMSCs from mouse and human endothelial cells and may be instructive for approaches to human tissue regeneration.
Journal ArticleDOI
Shift of EMT gradient in 3D spheroid MSCs for activation of mesenchymal niche function.
Sohee Jeon,Ho-Sun Lee,Ga-Young Lee,Gyeongsin Park,Tae-Min Kim,Jihye Shin,Cheolju Lee,Il-Hoan Oh +7 more
TL;DR: It is shown that MSCs in 3D spheroids undergo further progression towards the epithelial-mesenchymal transition (EMT), driven by upregulation of EMT-promoting microRNAs and suppression of E MT-inhibitory miRNAs, and the previously unrecognized functional parameters in M SCs are revealed.
Journal ArticleDOI
Functionally and Phenotypically Distinct Subpopulations of Marrow Stromal Cells Are Fibroblast in Origin and Induce Different Fates in Peripheral Blood Monocytes
Mineo Iwata,Richard Sandstrom,Jeffrey J. Delrow,John A. Stamatoyannopoulos,Beverly Torok-Storb +4 more
TL;DR: In vitro results show that the CD146(+) marrow stromal cells together with monocytes increase the expression of genes relevant to hematopoietic regulation.
References
More filters
Journal ArticleDOI
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Rafael A. Irizarry,Bridget G. Hobbs,Francois Collin,Yasmin Beazer-Barclay,Kristen J. Antonellis,Uwe Scherf,Terence P. Speed +6 more
TL;DR: There is no obvious downside to using RMA and attaching a standard error (SE) to this quantity using a linear model which removes probe-specific affinities, and the exploratory data analyses of the probe level data motivate a new summary measure that is a robust multi-array average (RMA) of background-adjusted, normalized, and log-transformed PM values.
Journal ArticleDOI
Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
Journal ArticleDOI
Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
Journal ArticleDOI
Osteoblastic cells regulate the haematopoietic stem cell niche
Laura M. Calvi,Gregor B. Adams,Kathryn W. Weibrecht,Jonathan M. Weber,David P. Olson,M. C. Knight,Roderick P. Martin,Ernestina Schipani,P. Divieti,F. R. Bringhurst,Laurie A. Milner,Henry M. Kronenberg,David T. Scadden +12 more
TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
Journal ArticleDOI
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
Related Papers (5)
A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more