Journal ArticleDOI
The emerging field of lipidomics
TLDR
Novel analytical approaches — in particular, liquid chromatography and mass spectrometry — for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.Abstract:
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large number of genetic studies and by many human diseases that involve the disruption of lipid metabolic enzymes and pathways. Examples of such diseases include cancer, diabetes, as well as neurodegenerative and infectious diseases. So far, the explosion of information in the fields of genomics and proteomics has not been matched by a corresponding advancement of knowledge in the field of lipids, which is largely due to the complexity of lipids and the lack of powerful tools for their analysis. Novel analytical approaches--in particular, liquid chromatography and mass spectrometry--for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.read more
Citations
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ToF-SIMS study of differentiation of human bone-derived stromal cells: new insights into osteoporosis
Kaija Schaepe,J Werner,Kristina Glenske,Tessa Bartges,Anja Henss,Marcus Rohnke,Sabine Wenisch,Jürgen Janek +7 more
TL;DR: In this article, the fatty acid composition of the outer plasma membranes of cells differentiated into the osteogenic and adipogenic direction is studied with surface-sensitive time-of-flight secondary ion mass spectrometry (ToF-SIMS).
Journal ArticleDOI
Penalized Variable Selection for Lipid-Environment Interactions in a Longitudinal Lipidomics Study.
TL;DR: A novel penalized variable selection method is developed to identify important lipid–environment interactions in a longitudinal lipidomics study and an efficient Newton–Raphson based algorithm was proposed within the generalized estimating equation (GEE) framework.
Journal ArticleDOI
Systems wide analyses of lipids in the brainstem during inflammatory orofacial pain - evidence of increased phospholipase A(2) activity.
TL;DR: Findings indicate enhanced PLA2 activity in the caudal medulla oblongata after inflammatory orofacial pain, as determined by lipidomics and systems wide analyses of lipids.
Journal ArticleDOI
Small extracellular vesicles (exosomes) and their cargo in pancreatic cancer: Key roles in the hallmarks of cancer.
Lily M. Channon,Victoria M. Tyma,Zhihong Xu,David W. Greening,Jeremy S. Wilson,Chamini J. Perera,Minoti V. Apte +6 more
TL;DR: A review of the role of extracellular vesicles, their subtypes and their oncogenic cargo (as characterised by targeted studies as well as agnostic '-omics' analyses) in the pathobiology of pancreatic cancer is presented in this paper .
Journal ArticleDOI
The Role of Lipids, Lipid Metabolism and Ectopic Lipid Accumulation in Axon Growth, Regeneration and Repair after CNS Injury and Disease
Debasish Roy,Andrea Tedeschi +1 more
TL;DR: In this article, the role of lipids, lipid metabolism and ectopic lipid accumulation in axon growth, regeneration and spinal cord repair is discussed, and molecular and pharmacological strategies to fine-tune lipid composition and energy metabolism in neurons and non-neuronal cells that can be exploited to improve neurological recovery after CNS trauma and disease.
References
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