Journal ArticleDOI
The emerging field of lipidomics
TLDR
Novel analytical approaches — in particular, liquid chromatography and mass spectrometry — for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.Abstract:
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large number of genetic studies and by many human diseases that involve the disruption of lipid metabolic enzymes and pathways. Examples of such diseases include cancer, diabetes, as well as neurodegenerative and infectious diseases. So far, the explosion of information in the fields of genomics and proteomics has not been matched by a corresponding advancement of knowledge in the field of lipids, which is largely due to the complexity of lipids and the lack of powerful tools for their analysis. Novel analytical approaches--in particular, liquid chromatography and mass spectrometry--for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.read more
Citations
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Journal ArticleDOI
Global characterization of the photosynthetic glycerolipids from a marine diatom Stephanodiscus sp. by ultra performance liquid chromatography coupled with electrospray ionization-quadrupole-time of flight mass spectrometry
TL;DR: This is the first report on global identification of photosynthetic glycerolipids, including lipid classes, fatty acyl composition within lipids and the location of fatty acids in lipids, in the extract of marine microalgae by UPLC-ESI-Q-TOF MS directly.
Journal ArticleDOI
Schizophrenia: from the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers
Gerald Stöber,Dorit Ben-Shachar,Michal Cardon,Peter Falkai,Alfred N. Fonteh,Micha Gawlik,Birte Glenthøj,Edna Grünblatt,Assen Jablensky,Yong Ku Kim,Johannes Kornhuber,Thomas F. McNeil,Norbert Müller,Bob Oranje,Toshikazu Saito,Mohamed Saoud,Andrea Schmitt,Michal Schwartz,Johannes Thome,Marat Uzbekov,Nuria Durany,Peter Riederer +21 more
TL;DR: At present, not a single biological trait in schizophrenia is available which achieves sufficient specificity, selectivity and is based on causal pathology and predictive validity to be recommended as diagnostic marker.
Journal ArticleDOI
Advances in mass spectrometry imaging coupled to ion mobility spectrometry for enhanced imaging of biological tissues
TL;DR: This review highlights recent advances in the field focusing on promising applications of gas-phase ion mobility spectrometry technologies for metabolite, lipid and protein tissue imaging.
Journal ArticleDOI
Recent advances in lipidomics: Analytical and clinical perspectives
Sumit Sethi,Elisa Brietzke +1 more
TL;DR: Current advances in lipidomics technologies and their applications in disease biomarker discovery, and its clinical application are given, and the application of lipidomics in clinical studies may provide new insights into lipid profiling and pathophysiological mechanisms.
Journal ArticleDOI
Lipid Bilayers: The Effect of Force Field on Ordering and Dynamics.
David Poger,Alan E. Mark +1 more
TL;DR: Simulations of the sensitivity of the structure and dynamics of a fully hydrated pure bilayer of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine in molecular dynamics simulations to changes in force-field and simulation parameters have been assessed.
References
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