Journal ArticleDOI
The emerging field of lipidomics
TLDR
Novel analytical approaches — in particular, liquid chromatography and mass spectrometry — for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.Abstract:
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large number of genetic studies and by many human diseases that involve the disruption of lipid metabolic enzymes and pathways. Examples of such diseases include cancer, diabetes, as well as neurodegenerative and infectious diseases. So far, the explosion of information in the fields of genomics and proteomics has not been matched by a corresponding advancement of knowledge in the field of lipids, which is largely due to the complexity of lipids and the lack of powerful tools for their analysis. Novel analytical approaches--in particular, liquid chromatography and mass spectrometry--for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.read more
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A Snapshot on the Current Status of Alzheimer's Disease, Treatment Perspectives, in-Vitro and in-Vivo Research Studies and Future Opportunities.
Gizem Tezel,Selin Seda Timur,Ismail Bozkurt,Ö Faruk Türkoğlu,İpek Eroğlu,Emirhan Nemutlu,Levent Öner,Hakan Eroglu +7 more
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Sex specific differences in hepatic and plasma lipid profiles in healthy cats pre and post spaying and neutering: relationship with feline hepatic lipidosis.
Chiara Valtolina,Arie B. Vaandrager,Robert P. Favier,Maidina Tuohetahuntila,Anne Kummeling,Isabelle Jeusette,Jan Rothuizen,J.H. Robben +7 more
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Lipidomics: new approaches to the studies of cell signaling and prospects of use in medicine.
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Journal ArticleDOI
Changes in plasma phospholipids and sphingomyelins with aging in men and women: A comprehensive systematic review of longitudinal cohort studies.
TL;DR: The relationship between aging and alterations in the plasma phospholipids and sphingomyelins was summarized in this article, where a total of 1425 studies were identified and full texts of 92 articles were evaluated.
References
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