Journal ArticleDOI
The emerging field of lipidomics
TLDR
Novel analytical approaches — in particular, liquid chromatography and mass spectrometry — for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.Abstract:
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large number of genetic studies and by many human diseases that involve the disruption of lipid metabolic enzymes and pathways. Examples of such diseases include cancer, diabetes, as well as neurodegenerative and infectious diseases. So far, the explosion of information in the fields of genomics and proteomics has not been matched by a corresponding advancement of knowledge in the field of lipids, which is largely due to the complexity of lipids and the lack of powerful tools for their analysis. Novel analytical approaches--in particular, liquid chromatography and mass spectrometry--for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.read more
Citations
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Journal ArticleDOI
Ultra-high performance liquid chromatography tandem mass spectrometry for comprehensive analysis of urinary acylcarnitines.
Azeret Zuniga,Liang Li +1 more
TL;DR: An enabling mass spectrometric method is reported for the analysis of lipid metabolites in order to define better the lipid metabolome in terms of chemical diversity and generate fragment ion spectra of these metabolites as a potential resource for unknown metabolite identification.
Sulfonolipids as novel metabolite markers of Alistipes and Odoribacter affected by high-fat diets
Alesia Walker,Barbara Pfitzner,Mourad Harir,Monika Schaubeck,Jelena Calasan,Silke S. Heinzmann,Dmitrij Turaev,Thomas Rattei,David Endesfelder,Wolfgang zu Castell,Dirk Haller,Michael Schmid,Anton Hartmann,Philippe Schmitt-Kopplin +13 more
TL;DR: A detailed molecular level characterization of an unusual class of bacterial sulfonolipids detected in mouse cecum, which was originally found in environmental microbes, enables explaining a part of the molecular complexity introduced by microbes to the mammalian gastrointestinal tract and can be used as chemotaxonomic evidence in gut microbiota.
Journal ArticleDOI
Triacylglyceride, antioxidant and antimicrobial features of virgin Camellia oleifera, C. reticulata and C. sasanqua Oils.
Xesús Feás,Leticia M. Estevinho,Carmen Salinero,Pilar Vela,M. J. Sainz,M. Vázquez-Tato,Julio A. Seijas +6 more
TL;DR: Virgin oils obtained from seeds of Camellia oleifera, camellia reticulata and Camellium sasanqua were studied for their triacylglyceride composition, antioxidant and antimicrobial activities and showed antimicrobial activity.
Journal ArticleDOI
Diet: the keystone of autism spectrum disorder?
Sara Peretti,Melania Mariano,C Mazzocchetti,Monica Mazza,Maria Chiara Pino,A Verrotti Di Pianella,Marco Valenti +6 more
TL;DR: This review describes the main current empirical studies that have examined the role of maternal diet during gestation and diet of ASD children as modifiable risk factors at the base of development or worsening of symptoms of autism.
References
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TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
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