Journal ArticleDOI
The emerging field of lipidomics
TLDR
Novel analytical approaches — in particular, liquid chromatography and mass spectrometry — for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.Abstract:
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large number of genetic studies and by many human diseases that involve the disruption of lipid metabolic enzymes and pathways. Examples of such diseases include cancer, diabetes, as well as neurodegenerative and infectious diseases. So far, the explosion of information in the fields of genomics and proteomics has not been matched by a corresponding advancement of knowledge in the field of lipids, which is largely due to the complexity of lipids and the lack of powerful tools for their analysis. Novel analytical approaches--in particular, liquid chromatography and mass spectrometry--for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.read more
Citations
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Journal ArticleDOI
Changes of Phospholipids in Fetal Liver of Mice Conceived by In Vitro Fertilization
TL;DR: By lipidomic analysis, the effect of ART on phospholipid profiles in the fetal liver in a mouse model is investigated for the first time and it is proposed that changes of LPC and PA may be one of the causes of the changes in glucose metabolism and vascular dysfunction in the mouse model of ART.
Journal ArticleDOI
Lipids in Ca2+ signalling—An introduction
Roger C. Hardie,Shmuel Muallem +1 more
TL;DR: The overall impact of lipids as signalling molecules and their role in Ca(2+) signalling, and this is the aim of this special issue of Cell Calcium.
Book ChapterDOI
Qualitative and Quantitative NMR Approaches in Blood Serum Lipidomics.
Banny Silva Barbosa,Lucas G. Martins,Tássia Brena Barroso Carneiro Costa,Guilherme Cruz,Ljubica Tasic +4 more
TL;DR: This chapter describes protocols that are used for extraction of blood serum lipids and their quantitative 1H NMR (1H qNMR) analysis in lipid extracts as well as 1h NMR edited by diffusion for direct blood serum lipid analysis.
Book ChapterDOI
Separation of Lipids
TL;DR: Lipidomics is a rather new area in which lipid profiles are used to identify physiologically important information and liquid chromatography plays an important role in all aspects of the isolation, identification and determination of lipid functions in biological systems.
Journal ArticleDOI
Lipidomic analysis of p‐chlorophenylalanine‐treated mice using continuous‐flow two‐dimensional liquid chromatography/quadrupole time‐of‐flight mass spectrometry
TL;DR: This work demonstrates the significant effects of serotonin deficiency on lipid metabolisms and will facilitate improved understanding of pathomechanisms in serotonin deficiency, particularly from a lipidomics perspective.
References
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TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
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