Journal ArticleDOI
The emerging field of lipidomics
TLDR
Novel analytical approaches — in particular, liquid chromatography and mass spectrometry — for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.Abstract:
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large number of genetic studies and by many human diseases that involve the disruption of lipid metabolic enzymes and pathways. Examples of such diseases include cancer, diabetes, as well as neurodegenerative and infectious diseases. So far, the explosion of information in the fields of genomics and proteomics has not been matched by a corresponding advancement of knowledge in the field of lipids, which is largely due to the complexity of lipids and the lack of powerful tools for their analysis. Novel analytical approaches--in particular, liquid chromatography and mass spectrometry--for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.read more
Citations
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Journal ArticleDOI
Mass spectrometry-based "omics" technologies in cancer diagnostics.
TL;DR: It can be envisaged that the "omics"-based cancer diagnostics will gradually enter into the clinic in next 10 years as an important supplement to current clinical diagnostics.
Journal ArticleDOI
Serum metabonomics study of adenine-induced chronic renal failure in rats by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
TL;DR: It is proved that metabonomics is a promising tool for disease research by indicating the perturbations of amino acid metabolism and phospholipid metabolism in adenine-induced CRF rats.
Journal ArticleDOI
A hyphenated microLC-Q-TOF-MS platform for exosomal lipidomics investigations: application to RCC urinary exosomes.
Piero Del Boccio,Francesca Raimondo,Damiana Pieragostino,L. Morosi,Gabriele Cozzi,Paolo Sacchetta,Fulvio Magni,Marina Pitto,Andrea Urbani +8 more
TL;DR: Differential lipid composition in RCC urinaryExosomes was achieved and tentatively identified by accurate mass, providing a preliminary indication of a relationship between lipid composition of urinary exosomes and RCC disease.
Journal ArticleDOI
Direct profiling of tissue lipids by MALDI-TOFMS.
TL;DR: An overview of the factors to consider when analyzing lipids directly from tissue and some recent examples of the use of MALDI-TOFMS for the direct profiling of lipids in tissue are given.
Journal ArticleDOI
Sensitive profiling of chemically diverse bioactive lipids.
TL;DR: High-resolution mass spectra of MAs derived from Mycobacterium bovis Bacille Camette-Guérin are compared during entry into nonreplicative conditions induced by oxygen deprivation (hypoxic dormancy) to provide detailed chemical information with relevance to drug development and immunobiology of mycobacteria.
References
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