Journal ArticleDOI
The emerging field of lipidomics
TLDR
Novel analytical approaches — in particular, liquid chromatography and mass spectrometry — for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.Abstract:
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large number of genetic studies and by many human diseases that involve the disruption of lipid metabolic enzymes and pathways. Examples of such diseases include cancer, diabetes, as well as neurodegenerative and infectious diseases. So far, the explosion of information in the fields of genomics and proteomics has not been matched by a corresponding advancement of knowledge in the field of lipids, which is largely due to the complexity of lipids and the lack of powerful tools for their analysis. Novel analytical approaches--in particular, liquid chromatography and mass spectrometry--for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.read more
Citations
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Journal ArticleDOI
Comprehensive Imaging of Porcine Adrenal Gland Lipids by MALDI-FTMS Using Quercetin as a Matrix
TL;DR: This work presents the largest group of lipid entities that have been analyzed in a single MS imaging study so far, and comprehensive profiles of the spatial distributions of lipids in porcine adrenal glands are shown here for the first time.
Journal ArticleDOI
Moving cancer diagnostics from bench to bedside
TL;DR: Although the present omic methods are not ready for immediate clinical use as diagnostic tools, it can be envisaged that simple, fast, robust, portable and cost-effective clinical diagnosis systems could be available in near future, for home and bedside use.
Journal ArticleDOI
Common cases of improper lipid annotation using high-resolution tandem mass spectrometry data and corresponding limitations in biological interpretation.
TL;DR: This poster presents a probabilistic procedure to characterize the response of the immune system to the presence of polymethine in the blood of an animal.
Journal ArticleDOI
Repeatability and reproducibility of desorption electrospray ionization-mass spectrometry (DESI-MS) for the imaging analysis of human cancer tissue: a gateway for clinical applications
Nima Abbassi-Ghadi,Emrys A. Jones,Kirill Veselkov,Juzheng Huang,Sacheen Kumar,Nicole Strittmatter,Ottmar Golf,Hiromi Kudo,Robert D. Goldin,George B. Hanna,Zoltan Takats +10 more
TL;DR: DESI-MS has acceptable levels of reproducibility for the analysis of lipids in human cancer tissue and is suitable for the purposes of clinical research and diagnostics.
Journal ArticleDOI
Nutritional Lipidomics: Molecular Metabolism, Analytics, and Diagnostics
Jennifer T. Smilowitz,Angela M. Zivkovic,Yu-Jui Yvonne Wan,Steve M Watkins,Malin L. Nording,Bruce D. Hammock,J. Bruce German +6 more
TL;DR: The field of lipidomics is providing nutritional science a more comprehensive view of lipid intermediates, and the strategy of combining tandem analytical methods to perform the sensitive, high-throughput, quantitative, and comprehensive analysis of lipid metabolites of very large numbers of molecules is poised to drive the field forward rapidly.
References
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