Journal ArticleDOI
The emerging field of lipidomics
TLDR
Novel analytical approaches — in particular, liquid chromatography and mass spectrometry — for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.Abstract:
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large number of genetic studies and by many human diseases that involve the disruption of lipid metabolic enzymes and pathways. Examples of such diseases include cancer, diabetes, as well as neurodegenerative and infectious diseases. So far, the explosion of information in the fields of genomics and proteomics has not been matched by a corresponding advancement of knowledge in the field of lipids, which is largely due to the complexity of lipids and the lack of powerful tools for their analysis. Novel analytical approaches--in particular, liquid chromatography and mass spectrometry--for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.read more
Citations
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Journal ArticleDOI
Lipidomics from an analytical perspective
Koen Sandra,Pat Sandra +1 more
TL;DR: The tools developed by lipid researchers in the past, complemented with the enormous advancements made in recent years in mass spectrometry and chromatography, and the implementation of sophisticated (bio)-informatics tools form the basis of current lipidomics technologies.
Journal ArticleDOI
Quantitative and wide-ranging profiling of phospholipids in human plasma by two-dimensional liquid chromatography/mass spectrometry.
TL;DR: A novel two-dimensional (2D) approach for sensitive and quantitative global analysis of phospholipids is presented and could distinguish plasma samples of Alzheimer's disease (AD) patients from those of age-matched healthy controls.
Journal ArticleDOI
An emerging role for metabolomics in nutrition science.
TL;DR: The purpose of the present review is to highlight some potential applications of metabolomics in nutrition research.
Journal ArticleDOI
Lipid metabolism in Alzheimer’s disease
Qiang Liu,Juan Zhang +1 more
TL;DR: This review integrates current knowledge about major lipid changes with the molecular mechanisms that underlie AD pathogenesis and concludes that lipid compositional diversity and the function of each of lipid species are currently poorly understood.
Journal ArticleDOI
Shotgun approach for quantitative imaging of phospholipids using nanospray desorption electrospray ionization mass spectrometry.
TL;DR: This proof-of-principle study demonstrates that this quantification approach can be extended to provide shotgun-like quantification of phospholipids in thin brain tissue sections by combining the quantitative data obtained in the individual pixels.
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