Journal ArticleDOI
The emerging field of lipidomics
TLDR
Novel analytical approaches — in particular, liquid chromatography and mass spectrometry — for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.Abstract:
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large number of genetic studies and by many human diseases that involve the disruption of lipid metabolic enzymes and pathways. Examples of such diseases include cancer, diabetes, as well as neurodegenerative and infectious diseases. So far, the explosion of information in the fields of genomics and proteomics has not been matched by a corresponding advancement of knowledge in the field of lipids, which is largely due to the complexity of lipids and the lack of powerful tools for their analysis. Novel analytical approaches--in particular, liquid chromatography and mass spectrometry--for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.read more
Citations
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2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas.
Pavithra Viswanath,Marina Radoul,Jose L. Izquierdo-Garcia,Wei Qiang Ong,Hema Artee Luchman,J. Gregory Cairncross,Bo Huang,Russell O. Pieper,Joanna J. Phillips,Sabrina M. Ronen +9 more
TL;DR: Inhibition of ER-phagy via pharmacological or molecular approaches restored phospholipid biosynthesis in IDHmut glioma cells, triggered apoptotic cell death, inhibited tumor growth, and prolonged the survival of orthotopicIDHmutglioma-bearing mice, pointing to a potential therapeutic opportunity.
Journal ArticleDOI
Lipidomics: Prospects from a technological perspective
TL;DR: The aim of this opinion article is to give the interested reader a concise but still comprehensive overview about the technological state of the art in lipidomics, current challenges and perspectives for future development.
Journal ArticleDOI
Comparative lipidomics analysis of cellular development and apoptosis in two Taxus cell lines.
TL;DR: The results suggest that the alternation of membrane phospholipids may regulate apoptosis, triggering an increase in taxol production of T. chinensis var.
Journal ArticleDOI
From simple to complex: investigating the effects of lipid composition and phase on the membrane interactions of biomolecules using in situ atomic force microscopy.
TL;DR: The in situ AFM measurements between SLBs of increasing complexity and biomolecules are excellent ways to investigate the effects of lipid composition and phase on the membrane-related processes.
Journal ArticleDOI
Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression.
Siamak MahmoudianDehkordi,Ahmed T. Ahmed,Sudeepa Bhattacharyya,Xianlin Han,Rebecca Baillie,Matthias Arnold,Michelle K. Skime,Lisa St. John-Williams,M. Arthur Moseley,J. Will Thompson,Gregory Louie,Patricio Riva-Posse,W. Edward Craighead,William M. McDonald,Ranga R. Krishnan,A. John Rush,A. John Rush,Mark A. Frye,Boadie W. Dunlop,Richard M. Weinshilboum,Rima Kaddurah-Daouk +20 more
TL;DR: In this article, a targeted metabolomics approach utilizing a panel of 180 metabolites was used to gain insights into mechanisms of action and response to citalopram and ESCOPRA this article.
References
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