Journal ArticleDOI
The emerging field of lipidomics
TLDR
Novel analytical approaches — in particular, liquid chromatography and mass spectrometry — for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.Abstract:
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large number of genetic studies and by many human diseases that involve the disruption of lipid metabolic enzymes and pathways. Examples of such diseases include cancer, diabetes, as well as neurodegenerative and infectious diseases. So far, the explosion of information in the fields of genomics and proteomics has not been matched by a corresponding advancement of knowledge in the field of lipids, which is largely due to the complexity of lipids and the lack of powerful tools for their analysis. Novel analytical approaches--in particular, liquid chromatography and mass spectrometry--for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.read more
Citations
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Journal ArticleDOI
Human serum lipidomics analysis revealed glyphosate may lead to lipid metabolism disorders and health risks.
Geng Zhang,Qian Zhang,Xin Liu,Mengting Gao,Xin Liu,Yifei Wang,Yueyue Chang,Zongli Huo,Li Fang Zhang,Jinjun Shan,Baoli Zhu,Weifeng Yao +11 more
TL;DR: In this paper , a nontargeted lipidomics study was conducted to investigate the 391 serum samples from the general population and chemical factory workers, and it was demonstrated that glyphosate caused significant perturbations of 115 differentially expressed lipids, including elevation of circulating diacylglycerols (DG), cholesteryl esters (CE), ceramides (Cer), sphingomyelins (SM), lysophosphatidylethanolamines (LPE) and phosphatidylcholines (PC).
Journal ArticleDOI
The role of lipid metabolism in cancer radioresistance
Journal ArticleDOI
Lipidome signatures of metastasis in a transgenic mouse model of sonic hedgehog medulloblastoma
Danning Huang,Jingbo Liu,Ronald C. Eldridge,David A. Gaul,Martin R. L. Paine,Karan Uppal,Tobey J. MacDonald,Facundo M. Fernández +7 more
TL;DR: This study provides deeper insights into dysregulations of lipid metabolism associated with SHH MB metastatic progression, and thus serves as a guide toward novel targeted therapies.
Book ChapterDOI
Chemical Probes of Sphingolipid Metabolizing Enzymes
TL;DR: Qualitative and quantitative mass spectrometry methods used for structural elucidation and quantitation of sphingolipids found in cells as well as tissues are explored.
Journal ArticleDOI
Metabolomic and Lipidomic Analysis of Bone Marrow Derived Macrophages
TL;DR: This method simultaneously extracts polar metabolites and lipids from BMDMs using a rapid two-phase extraction procedure and allows for a comprehensive characterization of cellular metabolism that can be used to understand the impact of a variety of environmental stimuli on macrophage metabolism and function.
References
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TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
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