Journal ArticleDOI
The emerging field of lipidomics
TLDR
Novel analytical approaches — in particular, liquid chromatography and mass spectrometry — for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.Abstract:
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large number of genetic studies and by many human diseases that involve the disruption of lipid metabolic enzymes and pathways. Examples of such diseases include cancer, diabetes, as well as neurodegenerative and infectious diseases. So far, the explosion of information in the fields of genomics and proteomics has not been matched by a corresponding advancement of knowledge in the field of lipids, which is largely due to the complexity of lipids and the lack of powerful tools for their analysis. Novel analytical approaches--in particular, liquid chromatography and mass spectrometry--for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.read more
Citations
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Journal ArticleDOI
Recent advances in the application of metabolomics to Alzheimer’s Disease
TL;DR: Current progress in the application of metabolomics in both animal models and in humans to further understanding of the mechanisms involved in AD pathogenesis is summarized.
Journal ArticleDOI
Microfluidics-based electrospray ionization enhances the intrasource separation of lipid classes and extends identification of individual molecular species through multi-dimensional mass spectrometry: development of an automated high-throughput platform for shotgun lipidomics.
TL;DR: The use of microfluidics and robotic sample handling substantially enhances intrasource separation of lipids in comparison to routine capillary interfaces and greatly facilitates the use of multi-dimensional mass spectrometry using shotgun lipidomics, thereby providing an automated and high-throughput platform for global analyses of cellular lipidomes.
Journal ArticleDOI
Lipidomics: a mass spectrometry based systems level analysis of cellular lipids.
TL;DR: In the decade since lipidomics was conceived much of the efforts have been on new methodologies, development of computer programs to decipher the gigabytes of raw data, and struggling with the highly variable nature of biological systems.
Journal ArticleDOI
Lipid pathway alterations in Parkinson's Disease primary visual cortex
Danni Cheng,Andrew M. Jenner,Guanghou Shui,Wei Fun Cheong,Todd W. Mitchell,Todd W. Mitchell,Jessica R. Nealon,Woojin S. Kim,Woojin S. Kim,Heather McCann,Markus R. Wenk,Glenda M. Halliday,Glenda M. Halliday,Brett Garner,Brett Garner,Brett Garner +15 more
TL;DR: The data indicate that changes in lipid metabolism occur in the Parkinson's disease visual cortex in the absence of obvious pathology, which suggests that normalization of lipid metabolism and/or oxidative stress status in the visual cortex may represent a novel route for treatment of non-motor symptoms, such as visual hallucinations, that are experienced by a majority of Parkinson's patients.
Journal ArticleDOI
Profiling lipid changes in plant response to low temperatures
TL;DR: An electrospray ionization tandem mass spectrometry (ESI-MS/MS)-based approach has been used to quantitatively profile membrane lipid molecular species in plant response to low temperatures.
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