Journal ArticleDOI
The emerging field of lipidomics
TLDR
Novel analytical approaches — in particular, liquid chromatography and mass spectrometry — for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.Abstract:
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large number of genetic studies and by many human diseases that involve the disruption of lipid metabolic enzymes and pathways. Examples of such diseases include cancer, diabetes, as well as neurodegenerative and infectious diseases. So far, the explosion of information in the fields of genomics and proteomics has not been matched by a corresponding advancement of knowledge in the field of lipids, which is largely due to the complexity of lipids and the lack of powerful tools for their analysis. Novel analytical approaches--in particular, liquid chromatography and mass spectrometry--for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.read more
Citations
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Journal ArticleDOI
Current Applications of Liquid Chromatography/Mass Spectrometry in Pharmaceutical Discovery After a Decade of Innovation
TL;DR: A review of recent trends for these three core disciplines in biology, chemistry, and drug disposition presents seminal examples where LC/MS has altered the current approach to drug discovery.
Journal ArticleDOI
Lipidomics applications in health, disease and nutrition research.
Sharon Murphy,Anna Nicolaou +1 more
TL;DR: Progress in the field of lipidomics has been greatly facilitated by recent advances in MS and includes a range of analytical platforms supporting applications spanning from qualitative and quantitative assessment of multiple species to lipid imaging.
Journal ArticleDOI
Lipidomics of host-pathogen interactions.
TL;DR: Novel biochemical analytics in combination with cell and molecular biology are a promising recipe for dissecting the roles of lipids in host–pathogen interactions.
Journal ArticleDOI
A review of lipidomic technologies applicable to sphingolipidomics and their relevant applications
Xianlin Han,Xuntian Jiang +1 more
TL;DR: This review article will add to the readers understanding of the advantages and limitations of each developed method for the analysis of a cellular sphingolipidome.
Journal ArticleDOI
Enrichment of extracellular vesicles from tissues of the central nervous system by PROSPR
TL;DR: The optimized use of PROSPR represents an easy-to-perform and inexpensive method of enriching EVs from human CNS tissues for detailed characterization by ‘omics’ technologies and it is predicted that widespread use of the methodology described herein will greatly accelerate the study of EVs biology in neuroscience.
References
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