Journal ArticleDOI
The emerging field of lipidomics
TLDR
Novel analytical approaches — in particular, liquid chromatography and mass spectrometry — for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.Abstract:
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large number of genetic studies and by many human diseases that involve the disruption of lipid metabolic enzymes and pathways. Examples of such diseases include cancer, diabetes, as well as neurodegenerative and infectious diseases. So far, the explosion of information in the fields of genomics and proteomics has not been matched by a corresponding advancement of knowledge in the field of lipids, which is largely due to the complexity of lipids and the lack of powerful tools for their analysis. Novel analytical approaches--in particular, liquid chromatography and mass spectrometry--for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.read more
Citations
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Unraveling lipid metabolism in maize with time‐resolved multi‐omics data
Francisco de Abreu e Lima,Kun Li,Weiwei Wen,Jianbing Yan,Zoran Nikoloski,Zoran Nikoloski,Lothar Willmitzer,Yariv Brotman +7 more
TL;DR: To predict the function of maize genes involved in lipid biosynthesis, transcriptomic and lipidomic data sets from leaves of B73 and the high-oil line By804 are assembled and the proposed approach provides high-confidence candidates for experimental testing in maize and model plant species.
Journal ArticleDOI
Cell membranes: A subjective perspective.
TL;DR: A short summary of the challenges that this field faces is presented and potential ways and means for coming to grips with the properties of this incredible fluid are discussed.
Journal ArticleDOI
Addressing the challenges of applying precision oncology.
TL;DR: Based on the continued rapid progression of genomic analysis, drug development, and clinical trial design, precision oncology will ultimately become the standard of care in cancer therapeutics.
Journal ArticleDOI
More from less: high-throughput dual polarity lipid imaging of biological tissues.
Shane R. Ellis,Joanna Cappell,Nina Ogrinc Potočnik,Benjamin Balluff,Julie Hamaide,Anne-Marie Van Der Linden,Ron M. A. Heeren +6 more
TL;DR: This work demonstrates how new high speed MALDI-MSI technologies combined with precise laser position control enables the acquisition of positive and negative ion mode lipid data from the same tissue section much faster than is possible with other MSI instruments.
Journal ArticleDOI
Profiles of photosynthetic glycerolipids in three strains of Skeletonema determined by UPLC-Q-TOF-MS
TL;DR: An exhaustive qualitative and quantitative profiling of the photosynthetic glycerolipids in three strains of the marine diatom Skeletonema sp.
References
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TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
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