Journal ArticleDOI
The emerging field of lipidomics
TLDR
Novel analytical approaches — in particular, liquid chromatography and mass spectrometry — for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.Abstract:
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large number of genetic studies and by many human diseases that involve the disruption of lipid metabolic enzymes and pathways. Examples of such diseases include cancer, diabetes, as well as neurodegenerative and infectious diseases. So far, the explosion of information in the fields of genomics and proteomics has not been matched by a corresponding advancement of knowledge in the field of lipids, which is largely due to the complexity of lipids and the lack of powerful tools for their analysis. Novel analytical approaches--in particular, liquid chromatography and mass spectrometry--for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.read more
Citations
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Journal ArticleDOI
Lipidomics applications for disease biomarker discovery in mammal models
TL;DR: Recent applications of lipidomics to understand animal models of disease such as metabolic syndromes, neurodegenerative diseases, cancer and infectious diseases are considered and the lipidomics for the future perspectives and their potential problems are discussed.
Journal ArticleDOI
Swelling-strengthening hydrogels by embedding with deformable nanobarriers.
Feng Wu,Yan Pang,Jinyao Liu +2 more
TL;DR: A swelling-strengthening phenomenon of polymer materials achieved by a bioinspired strategy involving Liposomal membrane nanobarriers embedded in a crosslinked network to regulate transmembrane transport is described.
Journal ArticleDOI
Alterations of specific lipid groups in serum of obese humans: a review.
Adriana Mika,Tomasz Sledzinski +1 more
TL;DR: The role of diet and endogenous lipid synthesis in the development of serum lipid alterations is discussed, along with potential application of various lipid compounds as risk markers for obesity‐related comorbidities.
Journal ArticleDOI
A method of coupling the Paternò–Büchi reaction with direct infusion ESI-MS/MS for locating the CC bond in glycerophospholipids
Craig A. Stinson,Yu Xia +1 more
TL;DR: The utility of coupling the PB reaction with infusion ESI-MS/MS was demonstrated by analyzing a yeast polar lipid extract where C[double bond, length as m-dash]C bond locations were revealed for 35 glycerophospholipids (GPs).
Journal ArticleDOI
Variation in the human lipidome associated with coffee consumption as revealed by quantitative targeted metabolomics.
Elisabeth Altmaier,Gabi Kastenmüller,Werner Römisch-Margl,Barbara Thorand,Klaus M. Weinberger,Jerzy Adamski,Thomas Illig,Angela Döring,Karsten Suhre +8 more
TL;DR: Results from a metabolomics study of coffee consumption demonstrate strong positive associations between coffee consumption and two classes of sphingomyelins and a negative association between Coffee consumption and long- and medium-chain acylcarnitines.
References
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