Journal ArticleDOI
The emerging field of lipidomics
TLDR
Novel analytical approaches — in particular, liquid chromatography and mass spectrometry — for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.Abstract:
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large number of genetic studies and by many human diseases that involve the disruption of lipid metabolic enzymes and pathways. Examples of such diseases include cancer, diabetes, as well as neurodegenerative and infectious diseases. So far, the explosion of information in the fields of genomics and proteomics has not been matched by a corresponding advancement of knowledge in the field of lipids, which is largely due to the complexity of lipids and the lack of powerful tools for their analysis. Novel analytical approaches--in particular, liquid chromatography and mass spectrometry--for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.read more
Citations
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Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery.
Roberto Romero,Shali Mazaki-Tovi,Shali Mazaki-Tovi,Edi Vaisbuch,Edi Vaisbuch,Juan Pedro Kusanovic,Juan Pedro Kusanovic,Tinnakorn Chaiworapongsa,Tinnakorn Chaiworapongsa,Ricardo Gomez,Jyh Kae Nien,Bo Hyun Yoon,Moshe Mazor,Jingqin Luo,David Banks,John A. Ryals,Chris Beecher +16 more
TL;DR: Among patients with spontaneous PTL with intact membranes, metabolic profiling of the amniotic fluid can be used to assess the risk of preterm delivery in the presence or absence of infection/inflammation.
Journal ArticleDOI
Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology
TL;DR: The studies demonstrate a sensitive and accurate method of detecting plasma desmosterol concentration and suggest that plasma des mosterol could become a powerful new specific biomarker for early and easy AD diagnosis.
Journal ArticleDOI
High throughput quantitative molecular lipidomics
TL;DR: A high throughput molecular lipidomic solution based on robotic assisted sample preparation and lipid extraction and multiple lipidomic platforms integrated with a sophisticated bioinformatics system that will contribute to basic research, nutritional research and promote the discovery of new disease biomarkers, disease related mechanisms of actions and drug targets.
Journal ArticleDOI
An extremely simple method for extraction of lysophospholipids and phospholipids from blood samples
Zhenwen Zhao,Yan Xu +1 more
TL;DR: This work has developed an extremely simple method for lysophospholipids and phospholipid extraction from human plasma or serum samples, which only utilizes a single methanol (MeOH) solvent and involves a single step of centrifugation.
Journal ArticleDOI
Biophysics in cancer: The relevance of drug-membrane interaction studies
TL;DR: The importance of anticancer drug-membrane interactions as a powerful strategy to improve cancer therapy is highlighted and biophysical techniques emerge as essential tools to unveil such interactions.
References
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TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
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