Journal ArticleDOI
The emerging field of lipidomics
TLDR
Novel analytical approaches — in particular, liquid chromatography and mass spectrometry — for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.Abstract:
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large number of genetic studies and by many human diseases that involve the disruption of lipid metabolic enzymes and pathways. Examples of such diseases include cancer, diabetes, as well as neurodegenerative and infectious diseases. So far, the explosion of information in the fields of genomics and proteomics has not been matched by a corresponding advancement of knowledge in the field of lipids, which is largely due to the complexity of lipids and the lack of powerful tools for their analysis. Novel analytical approaches--in particular, liquid chromatography and mass spectrometry--for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.read more
Citations
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DissertationDOI
The role of Symbiodinium membrane lipids in response to heat shock: implications for coral bleaching
TL;DR: The present thesis reports, for the first-time, upregulation of oxidized lipids derived from precursor chloroplast membranes and free fatty acids (FFA) in response to oxidative stress damage caused by heat.
Journal ArticleDOI
Phospholipid remodeling and its derivatives are associated with COVID-19 severity
Juntong Wei,Xiaoyu Liu,Weimin Xiao,Jiahua Lu,Li Guan,Zhangfu Fang,Jiaping Chen,Bao-hua Sun,Zongwei Cai,Xizhuo Sun,H. Chen,Nanshan Zhong,Zhigang Liu,Jun Yang,Xiao Jun Xiao,Shau Ku Huang +15 more
TL;DR: In this paper , the levels of circulating phospholipid metabolites and their relationship with COVID-19 severity were investigated, as well as the potential role of phospholine in disease progression.
Book ChapterDOI
Interplay Among Glycerophospholipid, Sphingolipid, and Cholesterol-Derived Lipid Mediators in Brain: A Matter of Life and Death
Journal ArticleDOI
LipidGO: database for lipid-related GO terms and applications
TL;DR: The usefulness of 'LipidGO' is demonstrated by two applications: identifying lipid-related gene products in model organisms and discovering potential novel lipid- related molecular functions.
Sampling and Sample Preparation in Bioanalysis
TL;DR: In this paper, the most important protocols that are applied for the sampling of gaseous, liquid, semisolid, and solid biological samples are discussed, and details on sample handling for analysis of major, minor, or trace components.
References
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Journal ArticleDOI
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
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TL;DR: The mammalian Tlr4 protein has been adapted primarily to subserve the recognition of LPS and presumably transduces the LPS signal across the plasma membrane.
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