Journal ArticleDOI
The emerging field of lipidomics
TLDR
Novel analytical approaches — in particular, liquid chromatography and mass spectrometry — for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.Abstract:
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large number of genetic studies and by many human diseases that involve the disruption of lipid metabolic enzymes and pathways. Examples of such diseases include cancer, diabetes, as well as neurodegenerative and infectious diseases. So far, the explosion of information in the fields of genomics and proteomics has not been matched by a corresponding advancement of knowledge in the field of lipids, which is largely due to the complexity of lipids and the lack of powerful tools for their analysis. Novel analytical approaches--in particular, liquid chromatography and mass spectrometry--for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.read more
Citations
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Proceedings ArticleDOI
Recursive feature elimination for brain tumor classification using desorption electrospray ionization mass spectrometry imaging
TL;DR: This work focuses on the problem of identifying lipid features to use as input for classification of tumor type classification, which could result in improvements in classifier performance, discovery of biomarkers, improved data interpretation, and patient treatment.
Journal ArticleDOI
A lipidomic concept in infectious diseases
TL;DR: Future lipidomics studies are the basic for detecting the lipid role in host-pathogen relations which help in therapy advances and biomarkers development.
Journal ArticleDOI
MALDI-TOF Fingerprinting of Seminal Plasma Lipids in the Study of Human Male Infertility
M. Camargo,Paula Intasqui,Camila Bruna de Lima,D.A. Montani,Marcilio Nichi,Eduardo Jorge Pilau,Fabio C. Gozzo,Edson Guimarães Lo Turco,Ricardo Pimenta Bertolla +8 more
TL;DR: The lipid profile and comparison of patterns altered in response to specific biological conditions were established and established the lipid fingerprinting of human seminal plasma by mass spectrometry as an analytical method to differentiate biological conditions.
Journal ArticleDOI
Lipidomic Biomarkers of Extracellular Vesicles for the Prediction of Preterm Birth in the Early Second Trimester
Qianqian Zhao,Zhen Ma,Xinran Wang,Minling Liang,Wenjing Wang,Fengxia Su,Huanming Yang,Ya Gao,Yan Ren +8 more
TL;DR: Differences in lipids in plasma, microvesicles (MVs) and exosomes (Exos) between 27 preterm and 66 full-term pregnant women in the early second trimester are investigated using an untargeted lipidomics approach to provide useful information for the early prediction of preterm birth and a better understanding of the underlying mechanisms and intervention of pre term birth.
Journal ArticleDOI
Dual parallel mass spectrometry for lipid and vitamin D analysis.
TL;DR: This work describes the approaches that employ two mass spectrometers in parallel or in a column-switching configuration that allows multiple ionization modes and types of experiments to be conducted simultaneously during a single chromatographic run, and demonstrates how use of two systems can reduce or eliminate the need for repeat injections and repetitive experiments.
References
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