National Defence University, Pakistan

About: National Defence University, Pakistan is a(n) education organization based out in Islamabad, Pakistan. It is known for research contribution in the topic(s): Decision support system & Population. The organization has 802 authors who have published 816 publication(s) receiving 3701 citation(s). The organization is also known as: National Defence University of Pakistan & National Defence University Islamabad.

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Abstract: Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Potential of adaptive neuro fuzzy inference system for evaluating the factors affecting steel-concrete composite beam's shear strength

Abstract: Structural design of a composite beam is influenced by two main factors, strength and ductility. For the design to be effective for a composite beam, say an RC slab and a steel I beam, the shear strength of the composite beam and ductility have to carefully estimate with the help of displacements between the two members. In this investigation the shear strengths of steel-concrete composite beams was analyzed based on the respective variable parameters. The methodology used by ANFIS (Adaptive Neuro Fuzzy Inference System) has been adopted for this purpose. The detection of the predominant factors affecting the shear strength steel-concrete composite beam was achieved by use of ANFIS process for variable selection. The results show that concrete compression strength has the highest influence on the shear strength capacity of composite beam.

Side-polished multimode fiber biosensor based on surface plasmon resonance with halogen light.

Abstract: A side-polished multimode fiber sensor based on surface plasmon resonance (SPR) as the transducing element with a halogen light source is proposed. The SPR fiber sensor is side polished until half the core is closed and coated with a 37 nm gold thin film by dc sputtering. The SPR curve on the optical spectrum is described by an optical spectrum analyzer and can sense a range of widths in wavelengths of SPR effects. The measurement system using the halogen light source is constructed for several real-time detections that are carried out for the measurement of the index liquid detections for the sensitivity analysis. The sensing fiber is demonstrated with a series of refractive index (RI) liquids and set for several experiments, including the stability, repeatability, and resolution calibration. The results for the halogen light source with the resolution of the measurement based on wavelength interrogation were 3×10−6 refractive index units (RIUs). The SPR dip shifted in wavelength is used as a measure of the RI change at a surface, and this RI change varies directly with the number of biomolecules at the surface. The SPR dip shift in wavelength, which was hybridized at 0.1 μM of the target DNA to the probe DNA, was 8.66 nm. The all-fiber multimode SPR sensor, which has the advantages of being low cost, being disposable, having high stability and linearity, being free of labeling, and having potential for real-time detection, permit the sensor and system to be used in biochemical sensing and environmental monitoring.

Plasticized poly(lactic acid) with low molecular weight poly(ethylene glycol): Mechanical, thermal, and morphology properties

Abstract: Poly(lactic acid) PLA was plasticized with low molecular weight poly(ethylene glycol) PEG-200 to improve the ductility of PLA, while maintaining the plasticizer content at maximum 10 wt%. Low molecular weight of PEG enables increased miscibility with PLA and more efficient reduction of glass transition temperature (Tg). This effect is enhanced not only by the low molecular weight but also by its higher content. The tensile properties demonstrated that the addition of PEG-200 to PLA led to an increase of elongation at break (>7000%), but a decrease of both tensile strength and tensile modulus. The plasticization of the PLA with PEG-200 effectively lowers Tg as well as cold-crystallization temperature, increasing with plasticizer content. SEM micrographs reveal plastic deformation and few long threads of a deformed material are discernible on the fracture surface. The use of low molecular weight PEG-200 reduces the intermolecular force and increases the mobility of the polymeric chains, thereby improving the flexibility and plastic deformation of PLA.

How Does Authentic Leadership Influence Planned Organizational Change? The Role of Employees’ Perceptions: Integration of Theory of Planned Behavior and Lewin's Three Step Model

Abstract: Kurt Lewin has been regarded as the father of planned change. His classical three-step model though has provided the basis for different models of change, yet has been criticized for its linearity, unsuitability for continuous change and inability to incorporate leader–follower relationship dynamics. This study has responded to various criticisms by introducing new three-step model as a replica of the three-step model while integrating it with the theory of planned behaviour. For leader–follower relationship dynamics, this study tested the impact of well-needed authentic leadership on employee perceptions during change. Following positivistic approach and deductive reasoning, this study used causal design to collect primary data through Questionnaire survey based on simple random sampling technique. The data were collected from 258 employees of three public sector hospitals of Pakistan undergoing restructuring and analysed through structural equation modelling using AMOS. The results suggest that ...