Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaques
Xia Jin,Daniel E. Bauer,Sarah Tuttleton,Sharon R Lewin,Agegnehu Gettie,James Blanchard,Craig E. Irwin,Jeffrey T. Safrit,John E. Mittler,Leor S. Weinberger,Leondios G. Kostrikis,Linqi Zhang,Alan S. Perelson,David D. Ho +13 more
TLDR
It is demonstrated that CD8 cells play a crucial role in suppressing SIV replication in vivo and are examined using an anti-CD8 monoclonal antibody, OKT8F.Abstract:
To determine the role of CD8(+) T cells in controlling simian immunodeficiency virus (SIV) replication in vivo, we examined the effect of depleting this cell population using an anti-CD8 monoclonal antibody, OKT8F. There was on average a 99.9% reduction of CD8 cells in peripheral blood in six infected Macaca mulatta treated with OKT8F. The apparent CD8 depletion started 1 h after antibody administration, and low CD8 levels were maintained until day 8. An increase in plasma viremia of one to three orders of magnitude was observed in five of the six macaques. The injection of a control antibody to an infected macaque did not induce a sustained viral load increase, nor did it significantly reduce the number of CD8(+) T cells. These results demonstrate that CD8 cells play a crucial role in suppressing SIV replication in vivo.read more
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Success and failure of the cellular immune response against HIV-1
Stephen A. Migueles,Mark Connors +1 more
TL;DR: Although the authors now have a detailed picture of the cellular immune responses to HIV-1, important questions remain regarding the nature of these responses and how they arise.
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Impaired antibody response causes persistence of prototypic T cell-contained virus.
Andreas Bergthaler,Lukas Flatz,Admar Verschoor,Ahmed N. Hegazy,Martin Holdener,Katja Fink,Bruno Eschli,Doron Merkler,Rami Sommerstein,Edit Horvath,Marylise Fernandez,André Fitsche,Beatrice M. Senn,J. Sjef Verbeek,Bernhard Odermatt,Claire-Anne Siegrist,Daniel D. Pinschewer +16 more
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Safety and Immunogenicity of ALVAC vCP1452 and Recombinant gp160 in Newly Human Immunodeficiency Virus Type 1-Infected Patients Treated with Prolonged Highly Active Antiretroviral Therapy
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TL;DR: Vaccination with vCP1452 and recombinant gp160 appears safe and immunogenic in newly HIV-1-infected patients on HAART, with significant increases in anti-gp120 or anti-p24 antibody titers.
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Human immunodeficiency virus type 1- and cytomegalovirus-specific cytotoxic T lymphocytes can persist at high frequency for prolonged periods in the absence of circulating peripheral CD4(+) T cells.
Hans M. L. Spiegel,Graham S. Ogg,Elizabeth DeFalcon,Megan E. Sheehy,Simon Monard,Patrick A. J. Haslett,Geraldine M. Gillespie,Sean M. Donahoe,Henry Pollack,William Borkowsky,Andrew J. McMichael,Douglas F. Nixon +11 more
TL;DR: Virus-specific CD8+ T cells can be maintained in the peripheral circulation at high frequency in the absence of circulating peripheral CD4-cell count, but these cells may lack direct effector activity.
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CD8+ Cell Depletion Accelerates HIV-1 Immunopathology in Humanized Mice
Santhi Gorantla,Edward Makarov,Jennifer Finke-Dwyer,Catherine L. Gebhart,William Domm,Stephen Dewhurst,Howard E. Gendelman,Larisa Y. Poluektova +7 more
TL;DR: Data support a role of CD8+ cells in viral surveillance and the relevance of this humanized mouse model for the studies of HIV-1 pathobiology and virus-specific immunity.
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