Genetic convergence in the adaptation of dogs and humans to the high altitude environment of the Tibetan plateau
Guo-Dong Wang,Ruo-xi Fan,Weiwei Zhai,Fei Liu,Lu Wang,Li Zhong,Hong Wu,He-Chuan Yang,Shi-Fang Wu,Chun-Ling Zhu,Yan Li,Yun Gao,Ri-Li Ge,Chung-I Wu,Ya-Ping Zhang +14 more
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TLDR
It is found that the hemoglobin levels in village dogs from Tibet and those from Chinese lowlands are very similar between the two groups, suggesting that Tibetan dogs might share similar adaptive strategies as the Tibetan people.Abstract:
The high-altitude hypoxic environment represents one of the most extreme challenges for mammals. Previous studies of humans on the Tibetan plateau and in the Andes Mountains have identified statistical signatures of selection in different sets of loci. Here, we first measured the hemoglobin levels in village dogs from Tibet and those from Chinese lowlands. We found that the hemoglobin levels are very similar between the two groups, suggesting that Tibetan dogs might share similar adaptive strategies as the Tibetan people. Through a whole-genome sequencing approach, we have identified EPAS1 and HBB as candidate genes for the hypoxic adaptation on the Tibetan plateau. The population genetic analysis shows a significant convergence between humans and dogs in Tibet. The similarities in the sets of loci that exhibit putative signatures of selection and the hemoglobin levels between humans and dogs of the same environment, but not between human populations in different regions, suggests an extraordinary landscape of convergent evolution between human beings and their best friend on the Tibetan plateau.read more
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Advances and limits of using population genetics to understand local adaptation.
Peter Tiffin,Jeffrey Ross-Ibarra +1 more
TL;DR: Important limitations to population genetic analyses are highlighted including challenges with obtaining high-quality data, deciding which loci are targets of selection, and limits to identifying the genetic basis of local adaptation.
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Genetic signatures of high-altitude adaptation in Tibetans
Jian Yang,Zi-Bing Jin,Jie Chen,Xiu-Feng Huang,Xiaoman Li,Yuanbo Liang,Jian-Yang Mao,Xin Chen,Zhili Zheng,Andrew Bakshi,Dong-Dong Zheng,Mei-Qin Zheng,Naomi R. Wray,Peter M. Visscher,Fan Lu,Jia Qu +15 more
TL;DR: The largest genome-wide study in Tibetans to date detects signatures of natural selection at nine gene loci, two of which are strongly associated with blood phenotypes in present day Tibetans, and shows the genetic relatedness of Tibetans with other ethnic groups in China and estimates the divergence time between Tibetans and Han.
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Demographic history, selection and functional diversity of the canine genome
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Altitude Adaptation: A Glimpse Through Various Lenses
TL;DR: Genomic findings parallel observations conveyed by decades of physiological research: different continental populations, resident at high altitude for hundreds of generations, exhibit a distinct composite of traits at altitude, which will advance the understanding of both adaptive and non-adaptive responses to hypoxia.
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Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation
Li Yu,Guo-Dong Wang,Jue Ruan,Yongbin Chen,Cui-Ping Yang,Xue Cao,Xue Cao,Hong Wu,Yan Hu Liu,Zheng Lin Du,Xiaoping Wang,Jing Yang,Shao Chen Cheng,Li Zhong,Lu Wang,Xuan Wang,Jing Yang Hu,Lu Fang,Bing Bai,Kaile Wang,Na Yuan,Shi Fang Wu,Baoguo Li,Baoguo Li,Jin Guo Zhang,Ye Qin Yang,Cheng Lin Zhang,Yong Cheng Long,Hai Shu Li,Jing Yuan Yang,David M. Irwin,Oliver A. Ryder,Ying Li,Chung-I Wu,Chung-I Wu,Ya-Ping Zhang +35 more
TL;DR: Signs of selection between and within populations at genes involved in functions relevant to high-altitude adaptation are identified at genes related to lung function, DNA repair, and angiogenesis.
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TL;DR: A high-quality draft genome sequence of the domestic dog is reported, together with a dense map of single nucleotide polymorphisms (SNPs) across breeds, to shed light on the structure and evolution of genomes and genes.
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