Open Access
疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
Reads0
Chats0
TLDR
PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.Abstract:
抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。read more
Citations
More filters
Journal ArticleDOI
Raman spectrum of graphene and graphene layers.
Andrea C. Ferrari,Jannik C. Meyer,Vittorio Scardaci,Cinzia Casiraghi,Michele Lazzeri,Francesco Mauri,S. Piscanec,Da Jiang,K. S. Novoselov,S. Roth,A. K. Geim +10 more
TL;DR: This work shows that graphene's electronic structure is captured in its Raman spectrum that clearly evolves with the number of layers, and allows unambiguous, high-throughput, nondestructive identification of graphene layers, which is critically lacking in this emerging research area.
Journal ArticleDOI
Finding and evaluating community structure in networks.
TL;DR: It is demonstrated that the algorithms proposed are highly effective at discovering community structure in both computer-generated and real-world network data, and can be used to shed light on the sometimes dauntingly complex structure of networked systems.
Journal ArticleDOI
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
Martin Jinek,Krzysztof Chylinski,Krzysztof Chylinski,Ines Fonfara,Michael H. Hauer,Jennifer A. Doudna,Emmanuelle Charpentier +6 more
TL;DR: This study reveals a family of endonucleases that use dual-RNAs for site-specific DNA cleavage and highlights the potential to exploit the system for RNA-programmable genome editing.
Journal ArticleDOI
The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments
Stephen A. Bustin,Vladimir Benes,Jeremy A. Garson,Jan Hellemans,Jim F. Huggett,Mikael Kubista,Reinhold Mueller,Tania Nolan,Michael W. Pfaffl,Gregory L. Shipley,Jo Vandesompele,Carl T. Wittwer,Carl T. Wittwer +12 more
TL;DR: The Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines target the reliability of results to help ensure the integrity of the scientific literature, promote consistency between laboratories, and increase experimental transparency.
Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
References
More filters
Journal ArticleDOI
Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling
TL;DR: The x-ray crystal structure of a mammalian Shaker family potassium ion (K+) channel grew three-dimensional crystals, with an internal arrangement that left the voltage sensors in an apparently native conformation, allowing the investigation of the mechanism by which these channels sense cell membrane voltage.
Journal ArticleDOI
Skeleton of Euplectella sp.: Structural Hierarchy from the Nanoscale to the Macroscale
Joanna Aizenberg,James C. Weaver,James C. Weaver,James C. Weaver,Monica S. Thanawala,Monica S. Thanawala,Monica S. Thanawala,Vikram C. Sundar,Vikram C. Sundar,Vikram C. Sundar,Daniel E. Morse,Daniel E. Morse,Daniel E. Morse,Peter Fratzl +13 more
TL;DR: The structural properties of biosilica observed in the hexactinellid sponge Euplectella sp.
Journal ArticleDOI
Dynamic Shifts of Limited Working Memory Resources in Human Vision
Paul M. Bays,Masud Husain +1 more
TL;DR: It is shown that visual memory capacity is not fixed by the number of objects, but rather is a limited resource that is shared out dynamically between all items in the visual scene, which can be shifted flexibly between objects.
Journal ArticleDOI
High capacity hydrogen storage materials: attributes for automotive applications and techniques for materials discovery
TL;DR: A practical introduction to the field of hydrogen storage materials research is provided, with an emphasis on the properties necessary for a viable storage material, the computational and experimental techniques commonly employed in determining these attributes, and the classes of materials being pursued as candidate storage compounds.
Journal ArticleDOI
Performance of modularity maximization in practical contexts
Benjamin H. Good,Benjamin H. Good,Yves-Alexandre de Montjoye,Yves-Alexandre de Montjoye,Aaron Clauset +4 more
TL;DR: It is shown that the modularity function Q exhibits extreme degeneracies: it typically admits an exponential number of distinct high-scoring solutions and typically lacks a clear global maximum, implying that the output of any modularity maximization procedure should be interpreted cautiously in scientific contexts.